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The Indiana Pacers (2-13) hope to snap an eight-game road losing skid at the Cleveland Cavaliers (10-6) on November 21, 2025. Friday’s matchup between the Cavaliers and the Pacers has no set line.

Check out everything you need to know to know about the Cavaliers-Pacers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Cavaliers vs. Pacers Game Information and TV ChannelWhen: Friday, November 21, 2025 at 7 p.m. ETWhere: Rocket Arena in Cleveland, OhioTV: Amazon Prime VideoLive Boxscore: FOX Sports

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Cavaliers vs. Pacers Prediction

ATS Pick:
O/U Pick: Under ()
Score Prediction: Cavaliers 126 – Pacers 108

Cavaliers Recent TrendsThe Cavaliers are 5-5 against the spread and 7-3 overall over their past 10 games.The Cavaliers are 6-10-0 against the spread this year.Cavaliers games this year have hit the over eight times in 15 opportunities (53.3%).The Cavaliers score 119.9 points per game, only 3.2 fewer points than the 123.1 the Pacers give up.Cleveland has a 3-3 record against the spread and a 5-1 record overall when scoring more than 123.1 points.The Cavaliers make 45.8% of their shots from the field this season, which is 2.4 percentage points lower than the Pacers have allowed to their opponents (48.2%).The Cavaliers have covered the spread in a lower percentage of their home games than away games. They have covered three times in nine games when playing at home, and they’ve covered three times in seven games on the road.In terms of point totals, Cleveland hits the over less often at home, as it has eclipsed the total three times in nine opportunities this season (33.3%). In away games, it has hit the over five times in seven opportunities (71.4%). As a moneyline favorite, the Cavaliers have taken six of eight games when playing at home, good for a .750 winning percentage. They have won three of six games on the road (.500) as a moneyline favorite.Cavaliers Recent Stats Stat Average Rank Points Scored 119.9 9 Points Allowed 116.1 15 Rebounds 43.6 20 Assists 27.0 10 Steals 9.2 9 Blocks 5.8 4 Cavaliers LeadersDonovan Mitchell posts 30.2 points, 5.3 assists and 4.5 rebounds per contest.Evan Mobley puts up 18.8 points, 8.6 boards and 4.0 assists per contest. Defensively, he averages 1.1 steals and 1.5 blocks.Jarrett Allen averages 14.8 points, 7.6 rebounds and 1.9 assists per game. At the other end, he averages 1.1 steals and 0.9 blocks.De’Andre Hunter averages 18.0 points, 2.8 assists and 4.7 boards.Craig Porter Jr. posts 6.1 points, 3.1 boards and 2.6 assists per contest. Defensively he averages 1.0 steal and 0.6 blocks.Pacers Recent TrendsThe Pacers are 3-7 against the spread and 2-8 overall in their last 10 contests.The Pacers have played 15 games, with six wins against the spread.Pacers games this year have gone over the point total 40% of the time (six out of 15 games with a set point total).The Pacers put up 6.0 fewer points per game (110.1) than the Cavaliers give up (116.1).When it scores more than 116.1 points, Indiana is 2-1 against the spread and 1-2 overall.The Pacers have shot at a 41.1% rate from the field this season, 5.1 percentage points below the 46.2% shooting opponents of the Cavaliers have averaged.In 2025-26 against the spread, the Pacers have a better winning percentage at home (.571, 4-3-0 record) than on the road (.250, 2-6-0).Looking at the over/under, Indiana’s games have gone over more frequently at home (four of seven, 57.1%) than on the road (two of eight, 25%).The Pacers’ winning percentage as moneyline favorites, both at home (0-1 record) and on the road (0-1), is .000.Pacers Recent Stats Stat Average Rank Points Scored 110.1 28 Points Allowed 123.1 27 Rebounds 46.3 8 Assists 23.5 29 Steals 6.3 30 Blocks 4.9 15 Pacers LeadersPascal Siakam is putting up 24.7 points, 6.9 rebounds and 4.9 assists per contest. He’s also draining 45.9% of his shots from the field and 35.1% from 3-point range, with 1.9 triples per game.Jarace Walker is putting up 9.9 points, 5.1 rebounds and 2.8 assists per game. He’s draining 30.6% of his shots from the floor and 28.9% from 3-point range, with 1.5 treys per game.Isaiah Jackson is putting up 8.2 points, 6.2 rebounds and 1.1 assists per game. He is draining 57.8% of his shots from the floor.Ben Sheppard gets the Pacers 6.9 points, 4.5 rebounds and 1.8 assists per contest while putting up 0.6 steals and 0.2 blocked shots.Jay Huff gets the Pacers 6.4 points, 3.0 rebounds and 0.9 assists per game while averaging 0.1 steals and 1.9 blocked shots (fifth in league).

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