Jan. 14, 2026, 6:33 a.m. ET

The Cleveland Cavaliers (22-19) and Philadelphia 76ers (22-16) meet Wednesday at Xfinity Mobile Arena in Philadelphia, Pennsylvania, in the front-end of a back-to-back set. Tip-off is scheduled for 7 p.m. ET (ESPN). Let’s analyze BetMGM Sportsbook’s NBA odds around the Cavaliers vs. 76ers odds and make our expert NBA picks and predictions for the best bets.

Season series: Cavaliers lead 1-0

The Cavaliers won the first meeting in Cleveland on Nov. 5, 132-121, although Philadelphia cashed as a 16.5-point underdog as the Over (235.5) cashed. Cleveland has won 4 of the past 5 meetings in this series since March 29, 2024, but Philadelphia is 6-1 against the spread (ATS) in the past 7 encounters, and 8-2 ATS in the past 10 meetings since 2023. The Over has cashed in 5 consecutive meetings, and 9 of the past 10 in the series.

The Cavaliers lost 123-112 at home against the Utah Jazz Monday as 13-point favorites as the Under (250.5) cashed. G Darius Garland did his best, posting 23 points with 8 assists with 5 3-pointers, while G Donovan Mitchell went for 21 points with 4 triples.

Cleveland has dropped 3 of the past 5 games, while going 1-5 ATS in the past 6 games, and 4-13 ATS in the previous 17 outings. The Under has cashed in 4 of the past 6 games, while going 6-3 in the past 9 outings.

The 76ers topped the Toronto Raptors 115-102 Monday as a 3.5-point favorite as the Under (221.5) cashed, rebounding from a 116-115 OT loss Sunday in the front end of the back-to-back set. G Tyrese Maxey rolled up 33 points with 6 3-pointers, and C Joel Embiid (rest) returned, going for 27 points and 8 boards.

Philly has won 6 of the past 8 games, while also going 6-2 ATS in the span. The Over has hit in 4 of the past 6 games, and 6 of the previous 9 contests.

Watch the NBA on Fubo!Cavaliers at 76ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:26 a.m. ET.

Moneyline (ML): Cavaliers -110 (bet $110 to win $100) | 76ers -110 (bet $110 to win $100)Against the spread: Cavaliers -1.5 (-102) | 76ers +1.5 (-118)Over/Under (O/U): 237.5 (O: -110 | U: -110)Cavaliers at 76ers key injuries

Cavaliers

F Max Strus (foot) outF Dean Wade (knee) out

76ers

G VJ Edgecombe (adductor) probableC Joel Embiid (knee, adductor, rest) probableF Paul George (knee, rest) probable

For most recent updates: Official NBA injury report.

Cavaliers at 76ers picks and predictionsPrediction

76ers 123, Cavaliers 118

The 76ERS (-110) are worth a look in what is essentially a pick ’em in the first of a 2-game set in Philadelphia.

As long as the Sixers do not rest Embiid or George unexpectedly, Philly should get the job done. Cleveland is extremely shaky lately, including a loss on its home court to a Utah Jazz team which suffered a franchise-worst 55-point loss in the previous game.

Philadelphia has had issues against Cleveland, but it is at home, and the 76ers are a little more consistent lately.

It makes little sense to take 76ers +1.5 (-118) rather than the moneyline.

AVOID.

The OVER 237.5 (-110) is the lean in Wednesday’s battle, but don’t get carried away.

The Over has cashed in 4 of the past 6 games for the 76ers, while going 8-4 across the previous 12 outings.

For the Cavaliers, they’ve allowed 123 or more points in 3 in a row, while the Over is 2-1. However, the Under is still 6-3 across the past 9 games, so tread lightly.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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