Jan. 28, 2026, 12:20 a.m. ET

The Los Angeles Lakers (28-17) visit the Cleveland Cavaliers (28-20) Wednesday. Tip-off from Cleveland, Ohio, is set for 7 p.m. ET (ESPN). Let’s analyze BetMGM Sportsbook’s NBA odds around the Lakers vs. Cavaliers odds and make our expert NBA picks and predictions for the best bets.

2024-25 season series: Cleveland won 2-0

Los Angeles picked up a 129-118 win over the Chicago Bulls Monday while covering as a 1.5-point road favorite as the Over (235.5) cashed. G Luka Doncic went off for 46 points, 12 assists, and 7 boards to lead the Lakers in all 3 categories. LA scored 23 points off 15 Chicago turnovers, also leading 52-48 in the paint and 24-19 in fast-break scoring.

Cleveland routed the Orlando Magic 114-98 Monday to cover as a 5-point home favorite with the Under (223.5) hitting. G Donovan Mitchell erupted for 45 points as Cleveland shot 53% from the field and 44% from 3-point range. The Cavs have won 4 straight, holding opponents under 100 points in 2 of those wins.

Watch the NBA on Fubo!Lakers at Cavaliers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:05 a.m. ET.

Moneyline (ML): Lakers +125 (bet $100 to win $125) | Cavaliers -155 (bet $155 to win $100)Against the spread (ATS): Lakers +3.5 (-120) | Cavaliers -3.5 (+100)Over/Under (O/U): 234.5 (O: -110 | U: -110)Lakers at Cavaliers key injuries

Lakers

G Austin Reaves (calf) out

Cavaliers

G Darius Garland (toe) outF De’Andre Hunter (knee) probableG Sam Merrill (hand) probableF Evan Mobley (calf) outF Max Strus (foot) out

For most recent updates: Official NBA injury report.

Lakers at Cavaliers picks and predictionsPrediction

Cavaliers 119, Lakers 116

BET CAVALIERS (-155).

Cleveland is the more complete team on both sides of the ball, and after having won 7 of their last 10 games, the Cavs are also the much hotter team. The Cavaliers are also 4-2 in their last 6 meetings with the Lakers, including winning each of the last 2 matchups.

The Lakers cannot consistently beat good teams, and even with so many injuries, the Cavaliers will still prove to be in a different class than L.A. here.

LEAN LAKERS +3.5 (-120).

The Lakers are 4-1 ATS in their last 5 games and are 24-20-1 ATS this season, much better than Cleveland’s 18-30 mark.

With both Garland and Mobley out, the Cavs will be missing 2 of their best 3 players offensively and their best defensive player. Look for Mitchell to score a lot, but look for Doncic to match that scoring, which will be enough for the Lakers to cover here.

This is a lean because the Lakers are terrible defensively, sitting at 25th in defensive rating and 18th in opponent points per game, so the Cavs could make this one a blowout behind an explosive scoring night from Mitchell.

LEAN OVER 234.5 (-110).

The Over has hit in 5 of LA’s last 9 games and is 26-19 for the Lakers this season. For Cleveland, the Over is 2-1 in its last 3 home games. The Over has also hit in 3 of the last 4 matchups between these squads.

With Mobley out and very few good perimeter defenders on either team, look for this to be an offensive clash rather than a defensive battle.

This is a very slight lean as the O/U is 5-5 in both Cleveland and LA’s last 10 games overall and in their last 10 matchups against each other.

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