Raiders at Chargers odds, picks and predictions

Updated Sept. 19, 2026, 9:45 p.m. ET

The Las Vegas Raiders (1-0) and the LA Chargers (0-1) meet Sunday for their Week 2 game at SoFi Stadium in Inglewood, California. Kickoff is scheduled for 4:05 p.m. ET (CBS). Let’s analyze NFL odds around the Raiders vs. Chargers odds and make our expert NFL picks and predictions for the best bets.

The Raiders lead the all-time series 69-62-2, but the Chargers have won 4 in a row, sweeping the past 2 regular-season series. The last win by the Raiders was a 63-21 victory at Allegiant Stadium in Las Vegas on Dec. 14, 2023. The Chargers have covered 4 in a row in this series, too, while the Under is 4-1 in the past 5 meetings in Los Angeles.

The Raiders opened with a 27-13 win over the Miami Dolphins at home last Sunday, covering as a 3.5-point favorite as the Under (40.5) cashed. QB Kirk Cousins debuted with 3 passing TDs, including 2 to RB Ashton Jeanty. The Raiders’ star tailback rushed for 102 yards, while adding 6 catches, 45 yards and 2 scores.

The Chargers were stunned by the Arizona Cardinals, losing 26-14 at home despite being a 9.5-point favorite as the Under (47.5) came through. WR Ladd McConkey had 5 catches for 82 yards and a TD, but he left with a rib injury.

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Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9:20 p.m. ET.

Moneyline (ML): Raiders +240 (bet $100 to win $240) | Chargers -295 (bet $295 to win $100)Against the spread (ATS): Raiders +6.5 (-105) | Chargers -6.5 (-115)Over/Under (O/U): 43.5 (O: -108 | U: -110)Raiders at Chargers injuries

Raiders

CB Darien Porter (foot) outTE Brock Bowers (knee) doubtfulQB Aidan O’Connell (personal) questionable

Chargers

CB Elijah Molden (hamstring) outOT Trey Pipkins (knee) outCB Deane Leonard (abdomen) questionableWR Ladd McConkey (rib) questionable

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Raiders at Chargers picks and predictionsPrediction

Chargers 26, Raiders 20

The Chargers (-295) will cost you nearly 3 times your potential return. I expect LA to bounce back, but the way the Chargers played last week, it’s almost tempting to back the Raiders (+240). The key to this game is the health of McConkey. If he is inactive for Sunday’s game, a road win by Las Vegas wouldn’t be surprising.

PASS.

Back RAIDERS +6.5 (-105), regardless of the health of the top receiving threat for the Bolts. It would be a lot nicer if this were a flat 7 or 7.5. You could buy up before Sunday, as Raiders +7 (-125) – Alternate Spread isn’t priced out of line, and even Raiders +7.5 (-145) – Alternate Spread isn’t bad.

If McConkey is indeed active, we could see some movement. So it might behoove you to wait, rather than buying up early.

OVER 43.5 (-108) is the lean, but roll with a half-unit play at best.

The Under is 4-1 in the past 5 meetings at SoFi Stadium, so be mindful of that. Plus, we could see McConkey sidelined, and it appears Bowers will miss a second straight game for the Raiders. That would be a lot of offensive production on the shelf, so tread lightly.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.

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