SANTA CLARA – Brock Purdy’s layered passes and air-show spirals will target radically different receivers Sunday in Atlanta than his options three months ago in training camp.

Mike Evans may or may not be one of them.

Definitely not suiting up: Ricky Pearsall, De’Zhaun Stribling, Demarcus Robinson, Deebo Samuel, KhaDarel Hodge, and, oh yeah, Dante Pettis.

Christian Kirk, injured the first day of camp, may make his season debut Sunday, joining an eclectic mix with Brandin Cooks, Jordan Watkins, Jacob Cowing, Malik Turner and possibly a practice-squad callup. Those were Purdy’s targets in Thursday’s rainy, Evans-less practice.

No matter how many practice reps are spent with replacements, none will command Purdy’s trust more than George Kittle and Christian McCaffrey.

Evans’ status is most concerning. He’s been Purdy’s clutch-situation muse in their 6-0 start, even though separate injuries kept Evans from finishing 3-of-4 home games so far.

His Achilles tendinitis flared up so bad Sunday he hobbled to the locker room before halftime of that 23-17 escape against Washington. He didn’t practice all of last week nor has he this week, when he’s otherwise been spotted wearing hyper-recovery sneakers.

So, with next week’s bye upcoming, it would not seem likely that Evans, gritty as he is, plays in Atlanta, right?

“I wouldn’t say it’s not likely. It’s still TBD,” general manager John Lynch said on KNBR 680-AM. “We’ve got a couple more days and will take every bit of those to ascertain where Mike’s at. He’s done a really good job treating this thing and obviously we know of Mike’s toughness.”

The 49ers will rely on their patchwork unit to bridge the gap through their bye to a Nov. 8 restart against the Raiders. Samuel (hamstring) and Robinson (ankle) should be cleared by then, and so might Evans so long as his Achilles pain cooperates, whether he plays Sunday in Atlanta or not.

“Offensively I think we’ll be fine. We’ve got a ton of weapons,” Lynch said. “Post-bye, we’re going to be getting some guys back and we’ll continue to evaluate everything. But we’re going to get some things to feel like acquisitions with guys just getting healthy, and we’ll continue to monitor the rest of the league.”

Evans’ last meeting with the Falcons took an emotional toll on him. In returning from a broken collarbone, he had 132 yards on six catches, but his host Tampa Bay Bucs lost 29-28. Television cameras caught Evans walking off the field and up the stadium tunnel in disbelief over the Falcons’ winning drive that included a third-and-28 conversion.

Once Evans headed to the Levi’s Stadium locker room Sunday, Purdy attempted only nine more passes: 2-for-4 to Kittle, 3-for-4 to McCaffrey, and 0-for-1 to Cooks.

Kirk, meanwhile, has impressed in his second week of practice since his hamstring injury when training camp opened. “He’s been preparing mentally, so it’s impressive to see him step in and be sharp on the details,” offensive coordinator Klay Kubiak said.

YORK BACK IN BUSINESS

Jed York, the 49ers’ principal owner, returned from a six-game suspension this week and promptly attended the NFL’s fall meeting in New York. “We went through a full process to understand the facts, understand the issues,” NFL commissioner Roger Goodell said in Wednesday’s press conference. “We looked at it under our personal conduct policy, which, as you point out, applies to owners, commissioners, everybody else, and players. It’s something we feel strongly about. We need to represent ourselves and our organizations properly.”

York also drew a $500,000 fine in the wake of his August arrest in an Ohio prostitution sting and his no-contest plea to two misdemeanor charges. “We saw a violation and we dealt with it from a discipline standpoint that’s concluded now,” Goodell added.

York voluntarily skipped the 49ers’ first three games, including their season-opening win over the Rams in Melbourne, Australia. Goodell called the NFL’s Australian debut “a tremendous success on really every level. … To get 100,000 people on a Friday morning at 10:30 is pretty remarkable. It shows the passion. In all of Australia, I’ve never seen a region or country that had more of a passion for sports, and I think that was demonstrated.”

MUSTAPHA’S BIG FAN

Lynch, a Pro Football Hall of Fame safety, lauded Malik Mustapha’s “impactful football” on back-to-back plays to ruin Washington’s penultimate possession.

“What he did the other night is why I’ve always been bias toward the safety position, because it’s hard to take that position out of the game,” Lynch said. “That sequence at the end of the game, where on the third down, it looks like they have an 8- or 9-yard gain, and what does he do? He doesn’t break stride, makes a perfect form tackle, head up, in the strike zone, hits the guy, and he does not get another yard.”

Indeed, Mustapha stuffed Jeremy McNichols for no gain at the 17-yard line, setting up fourth-and-3.

“Then he shows off his coverage ability covering a receiver and fighting until the bitter end to get that football out,” Lynch added. “He comes up with a huge pass breakup. That’s the play of the game right there. That sequence encompasses the way Malik is playing. He’s doing everything well and is playing with tremendous execution and physicality.”

PARTICIPATION REPORT

Defensive end Mykel Williams returned to practice after getting Wednesday off to rest his surgically repaired right knee, which became sore and sent him to the sideline in the final minute of Sunday’s win.

Nick Bosa (calf) has not practiced since Sept. 24 warmups. Also out Thursday were Samuel, linebackers Luke Gifford and Garrett Wallow; cornerback Upton Stout; and, safeties Marques Sigle and Siran Neal.