The San Francisco 49ers and the rest of the league will learn their schedules on Wednesday, May 14.
The full schedule announcement will air on NFL Network at 5 p.m. PT with analysts breaking down the 2025 NFL regular season schedule by division and picking their top matchups and primetime games. The 49ers full 2025 schedule will also be announced on 49ers.com, the 49ers mobile app, and 49ers social media.
While fans still have to wait until next month for the schedule, the 49ers 2025 opponents are already set. The 49ers will host games against the Arizona Cardinals, Los Angeles Rams, Seattle Seahawks, Atlanta Falcons, Carolina Panthers, Jacksonville Jaguars, Tennessee Titans, and Chicago Bears. The team will play road games against the Arizona Cardinals, Los Angeles Rams, Seattle Seahawks, Cleveland Browns, Houston Texans, Indianapolis Colts, New Orleans Saints, New York Giants, and Tampa Bay Buccaneers.