Depth charts can change drastically in a single offseason, and that can significantly impact 2025 Fantasy football drafts. The Steelers moved on from running back Najee Harris this offseason, leaving Jaylen Warren and rookie Kaleb Johnson as their top options heading into the 2025 campaign. Johnson had 1,537 rushing yards and 21 rushing touchdowns at Iowa last year, and he should be an effective goal-line running back in the NFL. Is he one of the 2025 Fantasy football breakouts you should be targeting with your 2025 Fantasy football lineups?

Giants running back Cam Skattebo is another rookie looking to make an immediate impact after an impressive college career. Skattebo is also battling for a starting spot, so keeping an eye on those depth-chart battles is one way to build a winning Fantasy football strategy. Before crafting your 2025 Fantasy football draft strategy, be sure to check out the 2025 Fantasy football rankings and cheat sheets from the proven computer model at SportsLine.

Last year, the model accurately predicted that Commanders quarterback Jayden Daniels would comfortably outperform his ADP (QB13). The result: Daniels threw for 3,568 yards and 25 touchdowns with only nine interceptions and added 891 rushing yards with six more scores on the ground to take home NFL Offensive Rookie of the Year honors. He finished as QB5 in CBS Sports PPR leagues and was a great addition to Fantasy football lineups.

The same model has a proven track record providing Fantasy football tips, identifying A.J. Brown as a sleeper in 2020, nailing Jonathan Taylor’s monstrous season in 2021 and correctly predicting C.J. Stroud would take a step back in 2024. Additionally, it’s called past Fantasy football sleepers like Derrick Henry in 2019, Christian McCaffrey and Alvin Kamara in 2018, and Davante Adams in 2017. Anybody who banked on players like those made a run at their league title.

 The model is powered by the same people who generated projections for all three major Fantasy Football sites, and it beat human experts last season when there was a big difference in ranking. The 2025 Fantasy football PPR rankings and 2025 Fantasy football standard rankings update multiple times daily, so you’re always getting the best Fantasy football advice.

Now, SportsLine has simulated the entire NFL season 10,000 times and released its latest Fantasy football rankings 2025, along with plenty of sleepers, breakouts and busts. Head to SportsLine now to see them. 

Top 2025 Fantasy football breakouts

One of the 2025 Fantasy football breakouts the model is predicting: 49ers running back Isaac Guerendo. The 2024 fourth-round pick sustained MCL and ankle sprains in his left leg during the regular-season finale last year, but he is back to full health heading into the 2025 campaign. Guerendo was forced into action when Christian McCaffrey and Jordan Mason both got hurt, averaging 17.9 PPR points in four games when he played at least 50% of the snaps. 

San Francisco traded Mason to the Vikings, leaving Guerendo as the primary backup to McCaffrey. Given McCaffrey’s extensive injury history, there is a strong possibility that Guerendo receives significant playing time during his second season. The model has him ranked ahead of running backs like Mason, MarShawn Lloyd and Nick Chubb, making him a Fantasy football breakout to target this year. 

Another potential breakout that SportsLine’s Fantasy football rankings 2025 have identified: Jaguars wide receiver Travis Hunter, who has an over/under of 750.5 receiving yards. A lot is being made about how much he’ll play on both sides of the ball and how it may cut into his production offensively. However, Hunter regularly handled well over 100 snaps per game at Colorado and the Jaguars desperately need a receiver opposite Brian Thomas Jr. to balance the passing attack.

Hunter led the Big 12 in receptions (96) and receiving touchdowns (15) while also ranking second in the conference and fifth nationally in receiving yards (1,258). He’s got high-level body control and proven athleticism, and the model predicts that he outperforms receivers like Jameson Williams and Darnell Mooney, who both finished top 25 in the NFL in receiving yards last season. See which other Fantasy football breakouts 2025 to pick here.

How to find proven 2025 Fantasy football rankings

SportsLine is also extremely high on a rookie running back to make an immediate impact. The model ranks this player as a top-10 option ahead of more established stars like Christian McCaffrey and Bucky Irving. You can only see who it is, and the 2025 Fantasy football rankings for every player, at SportsLine.

So which 2025 Fantasy Football breakouts should you target, and which RB shocks the NFL with a top-10 performance? Visit SportsLine now to get 2025 Fantasy Football cheat sheets for every single position, all from the model that called Jayden Daniels’ breakout rookie season, and find out.

2025 Fantasy football ADP

(PPR, via CBS)

1. Bijan Robinson (1.92)
2. Ja’Marr Chase (2.23)
3. Saquon Barkley (4.00)
4. Jahmyr Gibbs (4.92)
5. CeeDee Lamb (5.92)
6. Justin Jefferson (6.77)
7. Christian McCaffrey (9.23)
8. Ashton Jeanty (9.38)
9. Malik Nabers (9.85)
10. Amon-Ra St. Brown (10.77)