Bills storyline to watch: Can the Bills’ defense rebound from last week’s loss to the Rams? The unit is coming off its worst performance of the season, allowing 44 points and conversions on 11 of 15 third-down attempts. A significant challenge awaits in the league’s highest-scoring offense (32.1 points per game). “I think we’ve got to get back to good fundamental football,” coach Sean McDermott said on the defense bouncing back. “I think that’s really where it starts and playing with a certain attitude.” — Alaina Getzenberg

Lions storyline to watch: The Lions are aware that this could be a Super Bowl LIX preview, but the mindset entering this week isn’t any different. Three of the four NFC North teams have at least nine wins, so Detroit has been tested within its division en route to clinching a playoff spot already. Safety Kerby Joseph is one of the guys in the locker room who isn’t allowing teammates to make this game any bigger than what it is. “Going against a team like this, I feel like they’ve got guys, but we’ve got guys also,” Joseph told ESPN. “It’s just a competition to go head-to-head against the best.” — Eric Woodyard

Stat to know: The Bills have scored 30-plus points in seven straight games, which is the longest streak in franchise history and one shy of the longest in NFL history.

Bold prediction: The Lions will block a punt. The Bills are allowing a 14% pressure rate on punts, per NFL Next Gen Stats. That’s the second-highest rate in the league, behind only the 49ers. — Walder

What’s at stake: The Lions have a 75.7% chance to earn the No. 1 seed in the NFC, according to ESPN Analytics, which increases to 84.9% with a win. The Bills’ odds of earning the No. 1 seed in the AFC increase to 30% with a win.

Fantasy X factor: Lions running backs David Montgomery and Jahmyr Gibbs. This duo is on fire this season, averaging 32.6 touches and 34.6 fantasy points per game behind a Detroit offensive line that ranks 13th in run block win rate (71.9%). The Bills’ defense gives up the third-most fantasy points per game to running backs. See Week 15 rankings. — Moody

Betting nugget: The Bills have gone over their team total in 11 of 13 games, which is the highest mark in the NFL.

Kahler’s pick: Lions 30, Bills 28

Moody’s pick: Bills 33, Lions 30

Walder’s pick: Lions 30, Bills 24

FPI prediction: DET, 57.5% (by an average of 2.6 points)