What to KnowThe San Francisco 49ers play their second 2025 NFL preseason game when they face the Las Vegas Raiders on Saturday at Allegiant Stadium after a joint practice on Thursday.As San Francisco seeks a bounce-back win following its 30-9 loss to the Denver Broncos last weekend, NBC Sports Bay Area’s Matt Maiocco listed his five 49ers to watch against the Raiders.Rising rookie receiver Jordan Watkins stood out against Denver, but he won’t play Saturday after sustaining a high ankle sprain that will keep him out of action for a month.Quarterback Brock Purdy and the starters are expected to play early in Saturday’s game.In need of defensive line help, the 49ers signed Shakel Brown to the roster. Tight end Ross Dwelley was released.
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