Stan Szeto-USA TODAY Sports
The San Francisco 49ers return to Levi’s Stadium to face the Los Angeles Chargers in their final preseason game of 2025. This matchup marks the 51st preseason meeting all-time between the two teams and the first since 2023. San Francisco looks to improve its record to 28-23 in the preseason series against the Chargers.
Previous game
The 49ers are coming off a 22-19 victory over the Las Vegas Raiders. Offensively, the team totaled 348 yards, led by quarterback Mac Jones, who completed 13 of 16 passes for 135 yards. Running back Jeff Wilson Jr. contributed eight carries for 16 yards, including a one-yard rushing touchdown.
Defensively, the 49ers notched 4.0 sacks and forced two turnovers. Cornerback Chase Lucas and safety Jaylen Mahoney each recorded an interception, while linebacker Trevis Gipson, defensive lineman Demone Harris, Lucas, and linebacker Nick Martin each registered 1.0 sack.
On special teams, kicker Jake Moody was five of six on field goal attempts, connecting from 30, 26, 50, 44, and 59 yards. His 59-yard game-winner came as time expired, sealing the victory for San Francisco.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Saturday, August 23 at 5:30 p.m. PT
Where is the game being played?
Levi’s Stadium in Santa Clara, California
Who are the head coaches?
49ers: Kyle Shanahan
Chargers: Jim Harbaugh
Betting Odds
As of August 19, the Chargers are favored by 1.5 points in this game, with an over/under set at 35.5 points.
What channel is the game on?
49ers Broadcast
Network: KPIX 5 and CW Bay Area
Play-by-Play: Guy Haberman
Color Analyst: Tim Ryan
Sideline Reporter: Vern Glenn
Chargers Broadcast
Network: CBS LA
Play-by-play: Noah Eagle
Color Analyst: Dan Fouts
Sideline Reporter: Jaime Maggio
What areas will receive the broadcast?
The broadcast will be viewable in the Bay Area and the Los Angeles area.
NFL Network will re-air the game on Saturday, August 23, at 10:00 p.m. PT, and Monday, August 25, at 10:00 p.m. PT.
Where can I stream the game?
NFL Network will stream the game on the channel’s available streaming platforms. NFL+ subscribers can stream the game in its entirety. Additionally, Bay Area fans can stream the game through the official 49ers app.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Bob Fitzgerald and Keena Turner will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Chargers Radio
Los Angeles area fans can listen on KFI AM-640, where Matt “Money” Smith and Daniel Jeremiah will call the game.
Adrian Garcia-Marquez and Francisco Pinto will call the game in Spanish on Que Buena Los Angeles FM-105.5/94.3.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Preseason Matchups: 50
Preseason Series: 49ers lead series 27-23
First Preseason Meeting: 8/3/68, Chargers win, 30-18, at SD
Last Preseason Meeting: 8/25/23, Chargers win, 23-12, at SF
Current Streak: Lost 1
Longest 49ers Win Streak: 8 (9/2/10 – 8/31/17)
Longest Chargers Win Streak: 4 (8/15/81 – 8/18/84)
Most 49ers Points: 41 (8/29/13): 49ers win, 41-6, at SD
Most Chargers Points: 35 (8/18/84): Chargers win, 35-15, at SD
49ers Shutouts: None
Chargers Shutouts: None
SD – San Diego, CA
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