What to KnowThe San Francisco 49ers welcome the Los Angeles Chargers to Levi’s Stadium on Saturday for their final preseason game before the start of the 2025 NFL regular season.Some familiar faces are back in Santa Clara for the matchup, including ex-49ers coach Jim Harbaugh and former No. 3 overall 2021 NFL Draft pick Trey Lance, who will see plenty of time at quarterback against his old team.San Francisco is dealing with several injuries, but two key players returned to practice this week in running back Isaac Guerendo and cornerback Renardo Green ahead of the team’s preseason finale.As the 49ers get in one final tune-up before their pivotal 2025 campaign begins, NBC Sports Bay Area’s Matt Maiocco listed his five players to watch against the Chargers.
Follow this live blog for the latest score updates, game highlights, news and analysis from Levi’s Stadium in Santa Clara: