The Buffalo Bills will face off against the Baltimore Ravens in a huge Sunday Night Football first-edition for the 2025 NFL season.
Kickoff is 8:20 p.m. ET at Highmark Stadium.
Utilize the interactive widget below to see the current spread, over/under, and moneyline odds and probabilities for the Ravens-Bills matchup at Highmark Stadium.
Ravens vs. Bills betting preview
This preview includes updated odds, Dimers’ best bets, and the predicted scoreline for the Baltimore Ravens vs. Buffalo Bills on Sunday Night Football of NFL Week 1.
Game details
Key information on the Ravens vs. Bills matchup, including where the game is and what time it kicks off.
Teams: Baltimore Ravens vs. Buffalo BillsDate: Sunday, September 7, 2025Kickoff: 8:20 p.m. ETLocation: Highmark StadiumNFL injuries: Check the latest updates to the official NFL injury reportOdds
Odds for the key markets in the Ravens-Bills NFL matchup.
Spread: Ravens +1.5 (-118), Bills -1.5 (+100)Moneyline: Ravens -108, Bills -108Total: Over/Under 50.5 (-110/-105)
The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.
Promos
Local Bills fans in New York can now unlock $300 in bonus bets for NFL Week 1 with these FanDuel and DraftKings promos. Meanwhile, the BetMGM bonus code “CUSE150″ and Bet365 bonus code “SYRACUSE” both unlock NFL betting deals for Ravens fans.
Expert prediction: Ravens vs. Bills
Utilizing state-of-the-art data analysis and computer power, the experts at Dimers have performed 10,000 simulations of the Ravens vs. Bills matchup.
According to Dimers’ famous predictive analytics model, the Bills are more likely to beat the Ravens at Highmark Stadium. This prediction is based on the model giving the Bills a 54% chance of winning the game.
Elsewhere on the betting board, Dimers predicts that the bookies have gotten it right and the Ravens and Bills each have a 50% chance of covering the spread, while the 50.5-point over/under is also considered an equal 50-50 chance of hitting.
These predictions and probabilities are accurate at the time of publication but are subject to potential changes.
Ravens vs. Bills best bet
Our top pick for the Ravens vs. Bills Week 1 NFL matchup is to bet on the Bills moneyline (-108).
This betting advice is formulated through detailed modeling and valuable betting intelligence, designed to bring you the best possible plays.
Score prediction for Ravens vs. Bills
Dimers’ predicted final score for the Baltimore vs. Buffalo game on Sunday has the Bills winning 25-24.
This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.
NFL Week 1: Ravens vs. Bills
Get ready for Sunday’s action between the Ravens and Bills in Week 1 of the National Football League season at Highmark Stadium, which is scheduled to start at 8:20 p.m. ET. We emphasize that all of the NFL predictions and NFL best bets on this page are based on 10,000 data-driven simulations of the Ravens vs. Bills game, and they are accurate at the time of publication. They aim to assist you make more informed choices when placing bets at online sportsbooks.
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