Chargers vs. Chiefs opening odds, betting trends ahead of Week 1 game

The Chargers open up the 2025 regular season against the Chiefs this Friday night in São Paolo, Brazil.

Here are the current betting odds for the Week 1 game, courtesy of DraftKings Sportsbook:

Betting Category Kansas City ChiefsLos Angeles ChargersSpread-3 (-115)+3 (-105)Moneyline-170+142Over/Under (Total Points)Over 45.5 (-110)Under 45.5 (-110)Trends to knowLos Angeles has lost its last seven straight games against Kansas City.The Chargers have a 5-0-1 against the spread (ATS) record in their last six Week 1 games away from home.The Chargers covered the spread in three of their last four meetings with the Chiefs.The Bolts struggle as underdogs, with a 2-8-1 ATS record in their last 11 games.The Under is 10-4 in the Chargers’ last 14 games and 6-1 in their last seven road game.