The San Francisco 49ers are doing their final maneuvers ahead of their 2025 season opener Sunday against Seattle, particularly in their wide receiver room.

After signing WR Russell Gage to a one-year deal a few days prior, San Francisco is releasing the 29-year-old, per ESPN’s Adam Schefter.

As mentioned in the reporting, the hope is that Gage will make his way to Kyle Shanahan and John Lynch’s practice squad in Santa Clara.

Roster juggling: 49ers releasing WR Russell Gage from their active roster, but intend to sign him to their practice squad and elevate him for Sunday’s game vs. Seattle if he does not sign elsewhere.

— Adam Schefter (@AdamSchefter) September 2, 2025

Brandon Aiyuk is going to miss the start of the season. Jauan Jennings’ availability (and contract) status is currently in question.

Demarcus Robinson is serving a three-game suspension to start the season. Rookie Jordan Watkins is still recovering from a high ankle sprain he suffered in their preseason debut.

Jacob Cowing, a 49ers 2024 fourth-round pick, will be out at least four weeks with a hamstring injury.

Ricky Persall and recently signed Skyy Moore and Marquez Valdes-Scantling will have to fill spots for facilitator Brock Purdy.

Some expect a heavier reliance on their run game (Christian McCaffrey) and veteran tight end George Kittle.

More San Francisco 49ers coverage on Sactown Sports

September has arrived, meaning that another season of San Francisco 49ers football is finally upon us.

During Tuesday morning’s edition of The Carmichael Dave Show with Jason Ross, The Athletic’s Matt Barrows joined the show to share his thoughts on the current state of the 49ers’ injury issues, share which recently-signed WR is in line to join the team for Seattle’s opener, and much more.

Plus, Matt explains why the running game will be leaned on heavily as San Francisco rolls out a healthy Christian McCaffrey and a new face in Brian Robinson Jr.

Read More:

Barrows: 49ers to lean on George Kittle & RBs early

Upcoming San Francisco 49ers Schedule

Sunday, September 7th – @ Seattle Seahawks – 1:05 PM PT  *Season opener*
Sunday, September 14th – @ New Orleans Saints – 10:00 AM PT
Sunday, September 21st – vs. Arizona Cardinals – 1:25 PM PT
Sunday, September 28th – vs. Jacksonville Jaguars – 1:05 PM PT
Thursday, October 2nd – @ Los Angeles Rams – 5:15 PM PT

Thank you for reading SactownSports.com. Follow us on Twitter and Google News, and subscribe to our YouTube channel.