USATSI
The 2025 NFL season is upon us, and Week 1 is chock-full of intriguing matchups, starting with Thursday night’s opener between the Dallas Cowboys and Philadelphia Eagles. There are plenty of big names on track to make headlines throughout the weekend, from Aaron Rodgers making his debut with the Pittsburgh Steelers and Micah Parsons taking the field as a Green Bay Packer to George Pickens catching passes opposite CeeDee Lamb for America’s Team.
Not every notable name will actually be on the field when the NFL returns in full force, however. That’s because injuries have already impacted all 32 clubs thanks to the toll of training camp and preseason.
Which ailments are most concerning? Which star players could be in danger of missing the first week of action? And which ones are set to play through pain as the season gets underway?
We’ve got you updated right here with final injury reports for each and every matchup on the Week 1 schedule, plus analysis regarding which key players are set to miss — or suit up for — their respective games:
NFL odds via FanDuel Sportsbook
Cowboys at Eagles (-8.5)
McKee’s absence means the Eagles will enter the season with last-minute trade acquisition Sam Howell as Jalen Hurts‘ top backup. Rookie Kyle McCord is also on the team’s practice squad, though he’d need to be promoted to the active roster to serve as an emergency third quarterback against Dallas. Better news for Philadelphia: Pro Bowl guard Landon Dickerson (back) and rookie safety Andrew Mukuba (hamstring) are both off the injury report, signaling their availability.
Two of the Cowboys’ most important pieces on both sides of the ball are also now good to go: Pro Bowl cornerback Trevon Diggs (knee) and 2024 first-round pick left tackle Tyler Guyton (knee). Both of their respective availabilities for Thursday night were up in the air. Diggs has been recovering from a second knee procedure in as many years all offseason, and his work running with the scout team defense in practice helped get him up to speed. Guyton suffered a fractured bone and a sprained ligament in his knee at training camp, but he will also be able to return in time for Week 1 in Philadelphia.Â
Notable inclusions here: Marquise Brown (ankle) is good to go out wide for Kansas City, and running back Najee Harris (eye) is on track to make his Chargers debut despite missing most of the summer due to a fireworks accident. Other Chiefs on track to suit up despite recent injuries include right tackle Jawaan Taylor and new cornerback Kristian Fulton.