Five NFL games we can’t wait to watch in the 2025 season
The schedule for the 2025 NFL season has been released. Here are a few games on our must-watch list.
Who will win on Friday, Sept. 5, in NFL Week 1?
The Kansas City Chiefs and Los Angeles Chargers play on Sept. 5 at Corinthians Arena in Sao Paulo, Brazil, in a game on the NFL Week 1 schedule.
What do NFL Week 1 odds say about the game? Who are the NFL Week 1 predictions and NFL Week 1 picks taking in the game?
Which team has the best chance to win the game according to NFL Week 1 win probabilities?
Check out The Arizona Republic’s score prediction for the game, as well as Chiefs vs Chargers picks, odds and win chances for the Sept. 5 NFL Week 1 game, which can be seen at 5 p.m. MST on YouTube (stream on YouTube).
NFL Week 1 picks: Cowboys vs Eagles | Chiefs vs Chargers | Buccaneers vs Falcons | Bengals vs Browns | Dolphins vs Colts | Panthers vs Jaguars | Raiders vs Patriots | Cardinals vs Saints | Steelers vs Jets | Giants vs Commanders | Titans vs Broncos | 49ers vs Seahawks | Lions vs Packers | Texans vs Rams | Ravens vs Bills | Vikings vs Bears | The Republic’s score predictions
NFL Friday prediction for Chargers vs Chiefs game
The Arizona Republic is predicting a 27-23 win for the Chiefs over the Chargers in the NFL Week 1 football game.
Jeremy Cluff writes: “This game is being played in Brazil, and it could be a good one. The Chargers have lost seven straight games to the Chiefs, an AFC West division rival. Patrick Mahomes and Travis Kelce will make it eight.”
NFL Friday picks for Chiefs vs Chargers game
Will the Chargers or Chiefs win the game in NFL Week 1?
Bookies.com says that point could be at a premium in Friday’s NFL game in Brazil, so bet the under in the Chiefs-Chargers point total.
Sports Betting Dime is taking the Chargers to beat the Chiefs in the game Friday.
Dimers.com predicts a final score of Chiefs 24, Chargers 21.
Fansided is predicting a 27-20 win for the Chargers over the Chiefs in the NFL Week 1 game.
NFL Friday win probabilities for Chargers vs Chiefs game
 The Chiefs have a 56.9% chance to beat the Chargers, according to ESPN.
The site gives the Chargers a 42.8% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
NFL Friday odds for Chiefs vs Chargers game
The Chiefs are a 3-point favorite over the Chargers in NFL Week 1 odds for the game Friday, courtesy of BetMGM Sportsbook.
Kansas City is -175 on the moneyline, while Los Angeles is +145.
The over/under (point total) is set at 46 points.
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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