Sean Barnard dives into the top player prop bets in the Kansas City Chiefs vs. Los Angeles Chargers Friday Night NFL matchup.

The NFL season is officially back. The Philadelphia Eagles and Dallas Cowboys kicked off the 2025 season with an NFC East rivalry matchup last night. We don’t have to wait long, as another divisional showdown will be taking place tonight as the Kansas City Chiefs and the Los Angeles Chargers face off. As part of the NFL’s International series, tonight’s matchup will be played at Corinthians Arena in São Paulo, Brazil.

The Chiefs are favored by three points and hold -166 odds on the moneyline on DraftKings Sportsbook. The Chargers hold +140 odds of getting the outright victory with the game total set at 46.5.

There are plenty of ways to get involved in the action beyond just backing a side. This article will look at my three favorite prop bets on DraftKings Sportsbook for the Friday night NFL action between the AFC West foes.

Chiefs vs. Chargers Best Prop Bets

Omarion Hampton Over 48.5 Rushing Yards (-110)

The Los Angeles Chargers established an identity as a run-oriented offense in the first season under Jim Harbaugh. But J.K. Dobbins and Gus Edwards are no longer with the team, leaving a lot of production to fill. Enter Omarion Hampton, whom the Chargers selected with the 22nd overall pick in this year’s NFL Draft. The North Carolina product ran for 3,164 yards and 30 touchdowns while adding 595 receiving yards and three touchdowns across the past two seasons.

Najee Harris will also receive carries, but he’s been limited in training camp and practice due to an offseason fireworks accident. He’s officially ready to play in tonight’s matchup, but he doesn’t have the. same level of explosion that Hampton possesses. It may take a few weeks for Hampton to separate himself as the clear lead back, but 48.5 rushing yards is still a very comfortable line.

Teams don’t use a first-round pick on a running back without some sort of plan to use him. Los Angeles rushed for 115+ yards as a team in nine games last year and averaged 107.3 rushing yards per game overall. Kansas City also allowed 108.1 rushing yards per game last year. Expect the Chargers to continue leaning on the rushing attack and unveil what Hampton can do in the season opener. Harris will likely get some action, so it’ll be key to watch how they split the carries tonight. Nonetheless, Hampton should get enough chances to record over 48.5 rushing yards.

Xavier Worthy Over 62.5 Receiving Yards (-113)

Xavier Worthy had a somewhat disappointing rookie season, finishing with 638 yards and six touchdowns on 59 receptions. He also added 104 rushing yards and three rushing touchdowns. Worthy did have some success down the stretch of the season. In the final three regular-season games, excluding the Week 18 rest, he tallied 21 receptions for 190 yards and two touchdowns.

This momentum carried over into the playoffs, where he recorded 287 yards and three touchdowns on 19 receptions. He tallied over 62.5 receiving yards in four of his final six games. The 22-year-old receiver should build off this heading into his season season. He should get additional looks since Rashee Rice is serving a suspension.

It felt like Andy Reid didn’t maximize Worthy’s skillset for much of last season. He’s too brilliant of a football mind to struggle utilizing Worthy again. Worthy should be in for a big season this year, and it should start tonight. He is a constant big-play threat and could record over 62.5 receiving yards with just one play if the opportunity arises.

Isiah Pacheco Over 10.5 Receiving Yards (-107)

Isiah Pacheco had some hype surrounding him heading into last season, but it was short lived as he fractured his fibula in Week 2. It kept him sidelined until Week 13. Pacheco is back this season with a vengeance and sits at the top of the Chiefs’ running back depth chart.

While most of his impact will surely be on the ground, his reception prop line is too low for my liking. Across the seven games he played last year, Pacheco tallied 12 receptions for 79 yards. Seven of these receptions came across the opening two games before the injury. In 2023, he tallied 44 receptions for 244 yards and had over 10.5 receiving yards in eight of the 14 games played. He also cleared this total in three of the four 2023 postseason games.

Brush off the lack of impact through the air to close last season due to injury. Pacheco never really settled back in after going through the rehab process and now had a full offseason to prepare. This season is a fresh slate, and Pacheco should make a greater impact in the passing game. In addition, the Chargers allowed the ninth-most receptions to opposing running backs last season. The 10.5 receiving yards line is a low enough bar that it could take just one reception to clear this.