Sunday marks the 2025 regular season opener for the New Orleans Saints, as they host the Arizona Cardinals. These teams last met up in Week 7 of the 2022 season, a 42-34 Cardinals victory in Arizona. It will be the first time that the Saints will host the Cardinals since Week 8 of 2019, a 31-9 New Orleans win. In fact, these teams have only played in New Orleans in four of their eleven matchups dating back to 1997.

The overall series between the Saints and Cardinals dates back to 1967, when they were the St. Louis Cardinals and New Orleans first entered the NFL. The all-time series between the two franchises is tied at 16 wins apiece. When the Cardinals were in St. Louis, they had a commanding 10-5 advantage in the series. Since they moved to Phoenix in 1987, New Orleans has dominated the series with an 11-6 mark.

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Saints vs. Cardinals Series History

Longest winning streak: 4 (by both teams)

Record against Arizona/Phoenix Cardinals: Saints (11-6)

Last meeting (2022): Cardinals (42-34)

Last meeting in New Orleans (2019): Saints (31-9)

There has been one playoff meeting between these two franchises. That occurred during the 2010 Divisional Playoffs. New Orleans defeated Arizona, the defending NFC champion, by a 45-14 score on their way to a victory in Super Bowl XLIV. It was the largest margin of victory by New Orleans in this series. The largest margin of victory by the Cardinals came in a 40-7 win in New Orleans during the 1980 season, when they were the St. Louis Cardinals.

Arizona quarterback Kyler Murray has faced the Saints twice. He is 1-1 in those games, with the loss coming in New Orleans during a 31-9 rout. Murray has a 62.9% completion percentage in those two outings, throwing for a total of 424 yards with 1 touchdown, no interceptions, and 5 sacks. This will be the first time Arizona head coach Jonathan Gannon will face the Saints as the one in charge. It will also be the first time Saints quarterback Spencer Rattler will play against Arizona and the first game of any kind for Kellen Moore as a head coach.

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Notable Numbers

New Orleans defensive end Cameron Jordan has faced the Cardinals five times with 5 sacks, 8 QB hits, and 9 tackles for loss.

The 1969 matchup between the Saints and St. Louis Cardinals was a 51-42 New Orleans victory. It was the first win by the Saints in this series and featured 345 passing yards and a then-franchise record 6 touchdown passes from New Orleans quarterback Billy Kilmer.

The winning team has scored at least 30 points in nine straight matchups between these teams.

This article originally appeared on Saints Wire: Inside the numbers: Diving into Saints vs. Cardinals series history