The Arizona Cardinals open their 2025 season as road favorites against the New Orleans Saints on Sunday at Caesars Superdome. With Kyler Murray healthy and a fresh set of offensive weapons around him, Arizona is looking to build early momentum in what’s expected to be a competitive NFC playoff picture. The Saints, meanwhile, turn to rookie quarterback Spencer Rattler in his first NFL start, hoping the home crowd can give New Orleans a spark in the opener.

Oddsmakers have Arizona as 6.5-point favorites, priced at -275 on the moneyline, while New Orleans sits at +240. The total is set at 43.5 points, reflecting expectations for a moderately low-scoring game. According to Dimers.com’s predictive model, the Cardinals have a 73% chance of winning after 10,000 simulations, with a projected 24-18 final score.

That said, the model also gives the Saints a 57% probability to cover the spread, keeping the door open for a competitive contest. Key playmakers include James Conner and Marvin Harrison Jr. for Arizona, while Alvin Kamara and Chris Olave headline the Saints’ offense. Kickoff is set for 1 p.m. ET, and all eyes will be on how Rattler handles the challenge of his NFL debut against a playoff-caliber defense.

Cardinals vs. Saints betting preview

Utilize the interactive widget below to discover the current spread, over/under, and moneyline betting odds and probabilities for the Cardinals-Saints game at Caesars Superdome.

This prediction and best bet for Sunday’s NFL matchup between the Cardinals and Saints is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Cardinals vs. Saints NFL game.

Teams: Arizona Cardinals vs. New Orleans SaintsDate: Sunday, September 7, 2025Kickoff: 1 p.m. ETLocation: Caesars SuperdomeNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL showdown between the Cardinals and Saints.

Spread: Cardinals -6.5 (-104), Saints +6.5 (-110)Moneyline: Cardinals -275, Saints +240Total: Over/Under 43.5 (-112/-108)

The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Cardinals vs. Saints

Utilizing state-of-the-art data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Sunday’s Cardinals vs. Saints game.

According to Dimers’ independent predictive analytics model, the Cardinals are more likely to beat the Saints at Caesars Superdome. This prediction is based on the model giving the Cardinals a 73% chance of winning the game.

Furthermore, Dimers predicts that the Saints (+6.5) have a 57% chance of covering the spread, while the 43.5-point over/under has a 52% chance of staying under.

As always, these predictions and probabilities are accurate at the time of publication but are subject to potential changes.

Cardinals vs. Saints best bet

Our top pick for the Cardinals vs. Saints Week 1 NFL matchup is to bet on the Saints +6.5 (-110).

This expert betting advice is formulated through comprehensive simulations and valuable betting intelligence, designed to help you make smarter investments.

Score prediction for Cardinals vs. Saints

Dimers’ predicted final score for the Arizona vs. New Orleans game on Sunday has the Cardinals winning 24-18.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL player props are an exciting way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Cardinals and Saints, along with projected player stats.

Arizona CardinalsFirst touchdown scorer predictionsJames Conner: 16.4% probabilityMarvin Harrison: 9.2% probabilityTrey McBride: 7.2% probabilityAnytime touchdown predictionsJames Conner: 52.4% probabilityMarvin Harrison: 34.0% probabilityTrey McBride: 28.0% probabilityProjected box score leadersQB passing yards: Kyler Murray, 227 yardsReceiving yards: Trey McBride, 64 yardsRushing yards: James Conner, 74 yardsNew Orleans SaintsFirst touchdown scorer predictionsAlvin Kamara: 12.6% probabilityChris Olave: 6.3% probabilityRashid Shaheed: 5.5% probabilityAnytime touchdown predictionsAlvin Kamara: 45.2% probabilityChris Olave: 26.1% probabilityRashid Shaheed: 23.1% probabilityProjected box score leadersQB passing yards: Spencer Rattler, 206 yardsReceiving yards: Chris Olave, 56 yardsRushing yards: Alvin Kamara, 62 yardsNFL Week 1: Cardinals vs. Saints

Get ready for Sunday’s matchup between the Cardinals and Saints in Week 1 of the National Football League season at Caesars Superdome, which is scheduled to start at 1 p.m. ET. We emphasize that all of the NFL best bets and NFL predictions in this article are derived from 10,000 data-driven simulations of the Cardinals vs. Saints matchup, and they are correct at the time of publishing. They aim to help you make more informed choices when placing bets at online sportsbooks.

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