The Indianapolis Colts open their 2025 season at home against the Miami Dolphins on Sunday, with plenty of attention on new quarterback Daniel Jones. Veteran teammates like Jonathan Taylor have praised Jones for his command of the offense and his ability to adjust at the line of scrimmage, noting how his leadership has set the tone in the huddle throughout the offseason. That presence will be critical as the Colts look to start strong against one of the AFC’s most explosive teams.

Oddsmakers see this game as a virtual coin flip. The Colts are slight 1.5-point favorites at Lucas Oil Stadium, while both teams sit at -108 on the moneyline. According to Dimers.com’s predictive model, Indianapolis has a 55% chance of victory after 10,000 simulations, with a projected 23-22 final score. The spread and total of 46.5 points each carry a 50-50 probability of hitting, underscoring how evenly matched these sides appear.

For the Dolphins, Tua Tagovailoa and Tyreek Hill headline a fast-paced offense that will test the Colts’ secondary, while De’Von Achane offers a big-play threat on the ground. Indianapolis counters with Taylor and wideouts Michael Pittman Jr. and Josh Downs, as Jones makes his debut in blue and white. Kickoff is set for 1 p.m. ET, and with both teams aiming to make early noise in the AFC, this opener carries plenty of intrigue.

Dolphins vs. Colts betting preview

Utilize the interactive widget below to see the latest spread, over/under, and moneyline odds and probabilities for the Dolphins-Colts matchup at Lucas Oil Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Dolphins and Colts is from Dimers.com, a reliable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Dolphins vs. Colts NFL game.

Teams: Miami Dolphins vs. Indianapolis ColtsDate: Sunday, September 7, 2025Kickoff: 1 p.m. ETLocation: Lucas Oil StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL matchup between the Dolphins and Colts.

Spread: Dolphins +1.5 (-118), Colts -1.5 (-102)Moneyline: Dolphins -108, Colts -108Total: Over/Under 46.5 (-110/-105)

The odds and lines featured here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Dolphins vs. Colts

Using state-of-the-art data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday’s Dolphins vs. Colts game.

According to Dimers’ famous predictive analytics model, the Colts are more likely to beat the Dolphins at Lucas Oil Stadium. This prediction is based on the model giving the Colts a 55% chance of winning the game.

Furthermore, Dimers predicts that the bookies have gotten it right and the Dolphins and Colts each have a 50% chance of covering the spread, while the over/under total of 46.5 points is also considered an equal 50-50 chance of hitting.

As always, these predictions and probabilities are correct at the time of publication but are subject to potential changes.

Dolphins vs. Colts best bet

Our top pick for the Dolphins vs. Colts Week 1 NFL matchup is to bet on the Colts moneyline (-108).

This betting advice is based on detailed modeling and valuable wagering intelligence, designed to assist you in making smarter decisions.

Score prediction for Dolphins vs. Colts

Dimers’ predicted final score for the Miami vs. Indianapolis game on Sunday has the Colts winning 23-22.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL prop picks are a great way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Dolphins and Colts, along with projected player stats.

Miami DolphinsFirst touchdown scorer predictionsDe’Von Achane: 14.5% probabilityTyreek Hill: 8.5% probabilityOllie Gordon: 6.6% probabilityAnytime touchdown predictionsDe’Von Achane: 55.5% probabilityTyreek Hill: 37.9% probabilityOllie Gordon: 30.6% probabilityProjected box score leadersQB passing yards: Tua Tagovailoa, 249 yardsReceiving yards: Tyreek Hill, 73 yardsRushing yards: De’Von Achane, 62 yardsIndianapolis ColtsFirst touchdown scorer predictionsJonathan Taylor: 15.0% probabilityMichael Pittman: 5.3% probabilityJosh Downs: 5.2% probabilityAnytime touchdown predictionsJonathan Taylor: 56.4% probabilityMichael Pittman: 25.5% probabilityJosh Downs: 24.8% probabilityProjected box score leadersQB passing yards: Daniel Jones, 213 yardsReceiving yards: Josh Downs, 52 yardsRushing yards: Jonathan Taylor, 83 yardsNFL Week 1: Dolphins vs. Colts

Get ready for Sunday’s action between the Dolphins and Colts in Week 1 of the National Football League season at Lucas Oil Stadium, which is scheduled to start at 1 p.m. ET. We emphasize that all of the NFL best bets and NFL predictions on this page are derived from 10,000 data-driven simulations of the Dolphins vs. Colts matchup, and they are correct at the time of publishing. They aim to assist you make better decisions when placing bets at online sportsbooks.

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