George Kittle and the San Francisco 49ers will visit Sam Darnold and the Seattle Seahawks on Sunday at 4:05 p.m. ET, in a matchup between a pair of the best offensive players in the NFL last season.
The Seahawks averaged 332.2 yards per game on offense last season, which ranked them 14th in the NFL. On defense, they ranked 14th, surrendering 332.7 yards per contest. On offense, the 49ers were a top-five unit last season, ranking fourth-best in the NFL by compiling 376.3 yards per game. They ranked eighth on defense (317.4 yards allowed per game).
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Seahawks vs 49ers: Live streaming info, TV channel & game timeGame day: Sunday, September 7, 2025Game time: 4:05 p.m. ETLocation: Seattle, WashingtonStadium: Lumen FieldTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
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Seahawks vs 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated Saturday at 8:29 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-1.5)Moneyline: 49ers (-119), Seahawks (-101)Total: 43.5 points
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