Texans at Rams odds, picks and predictions

The Houston Texans visit the LA Rams in Week 1 to start the 2025 season, a matchup between 2 teams that have made the playoffs in each of the last 2 years. Let’s analyze BetMGM Sportsbook’s NFL odds around the Texans vs. Rams odds and make our expert NFL picks and predictions for the best bets.

The Texans are coming off a 10-7 season in which they won the AFC South and made the playoffs for the second straight season, only to lose to the Kansas City Chiefs in the divisional round. They have a revamped offensive line after making wholesale changes in the offseason, notably with rookie Aireontae Ersery taking over at left tackle. Houston’s offense took a step back in 2024 under QB C.J. Stroud, but the young signal caller could be in for a bounce-back season with new OC Nick Caley calling the plays.

Like Houston, the Rams also went 10-7 and won their division in 2024, making the playoffs for the second consecutive year. WR Davante Adams was the Rams’ big offseason signing, with rookie TE Terrance Ferguson being the team’s top draft pick. QB Matthew Stafford dealt with a back injury throughout the summer, but is ready to go in Week 1.

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Texans at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:01 a.m. ET.

Moneyline (ML): Texans +140 (bet $100 to win $140) | Rams -165 (bet $165 to win $100)Against the spread (ATS): Texans +3 (-110) | Rams -3 (-110)Over/Under (O/U): 43.5 (O: -110 | U: -110)

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Texans at Rams key injuries

Texans

WR Christian Kirk (hamstring) outRB Joe Mixon (foot/ankle) out

Rams

LT Alaric Jackson (blood clots) will playQB Matthew Stafford (back) will playCB Ahkello Witherspoon (knee) will playTexans at Rams picks and predictionsPrediction

Rams 24, Texans 20

It’s always tough to predict outcomes in Week 1, not knowing exactly how each team will look. But on paper, the Rams are the healthier and more talented team on both sides of the ball. They have the receiving tandem to overcome Houston’s talented cornerback duo of Derek Stingley Jr. and Kamari Lassiter, as well as a rushing attack to wear down the Texans’ defense.

Still, at -165, it’s not worth taking the Rams on the moneyline. PASS here and bet on them to cover the spread.

The Rams are 3-point favorites over the banged-up Texans, a line that has bounced between 2.5 points and 3.5 points. Ideally, it’ll move back down to -2.5, but even at -3 (-110) it’s palatable to take the Rams.

Their defensive line could give the Texans’ O-line fits, forcing Stroud to check the ball down and get it out quickly, thus preventing big plays downfield. And with Mixon out, the Texans can’t exactly lean on a ground game. BET RAMS -3 (-110).

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On one hand, the Rams could come out of the gates slow with Stafford getting eased back into things. On the other, Sean McVay is an excellent game planner and has had months to prepare for the Texans. With Houston’s explosive offense, it could also put pressure on the Rams to be aggressive offensively.

At that key number of 43.5, we’d LEAN OVER 43.5 (-110).

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Texans at Rams odds, picks and predictions

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