The long wait is over for the 2025 NFL season, and Sunday is jam-packed with Week 1 battles fans won’t want to miss. The best way for you to play along is the use the newest Caesars Sportsbook promo code CBS20X, which gives new users 20 100% profit boosts after making a minimum $1 first bet when they sign up. The Week 1 NFL schedule features nine must-see division rivalries, like Giants vs. Commanders at 1 p.m. ET and 49ers vs. Seahawks at 4:05 p.m. ET. Football bettors can bet on both of these games at Caesars Sportsbook when they use Caesars promo code CBS20X.
On Sunday night, familiar foes Josh Allen and Lamar Jackson will rematch as the Bills host the Ravens at 8:20 p.m. ET. Buffalo has won 10 straight home games and is 10-5 against the spread over 15 games, so it’s no surprise the Bills are -1.5 favorites in the last Week 1 NFL odds at Caesars. Before locking in your Week 1 NFL picks on your favorite betting sites like Caesars, you’ll also want to be sure to check out the top NFL betting picks from SportsLine’s proven computer model. Claim the latest Caesars bonus code here, where new users get twenty 100% sportsbook profit boosts with a $1 bet when they use code CBS20X:
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Best Week 1 NFL picks at Caesars Sportsbook:
Combining the model’s three picks into a Week 1 NFL parlay at Caesars would result in a payout of +612 (risk $100 to win $612). Bet it at Caesars here:
Commanders -6 vs. Giants (-110)
Washington went 7-2 against the spread at home last season and was 6-2 ATS as the home favorite, and covered in seven of eight games starting with a Week 2 home win against the Giants. Jayden Daniels is set up to have another stellar season with Deebo Samuel and Laremy Tunsil added to the offense, compared to a Giants offense that hasn’t yet found its identity with Russell Wilson under center. New York only covered the spread four times last season, which could be why the SportsLine model projects the Commanders to cover in over 60% of simulations.
Buccaneers -1 vs. Falcons (-105)
This bet may seem tricky since Tampa Bay is 1-4 in its last five games against the Falcons. However, the Bucs got hot at the end of last season and are returning a veteran corps, including Baker Mayfield, Mike Evans and Bucky Irving. This will be the first season the Falcons will have Michael Penix Jr. under center full-time, and the jury is still out on how he will perform after not playing in any preseason games. The SportsLine model projects the Buccaneers will cover in well over 60% of simulations.
49ers vs. Seahawks Under 43.5 (-110)
These NFC West rivals have engaged in many high-scoring battles, but played to a 20-17 Seahawks victory when they last met in 2024. Seattle is incorporating a more defense-first mentality under head coach Mike Macdonald, while San Francisco’s defense welcomes Robert Saleh back to the sidelines. Both sides have kinks to iron out on offense, with Brock Purdy playing with an injured receiving corps and the Seahawks entering a season without Geno Smith or DK Metcalf. The model shows the Under hitting in over 50% of simulations on Sunday.
Want more Week 1 NFL picks?
You’ve seen the model’s Week 1 NFL best bets. Now, get against the spread, total and money-line picks for every Week 1 NFL game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see Week 1 picks and predictions from NFL expert R.J. White. Visit SportsLine to see his best bets. In addition, SportsLine’s Sia Nejad, who is 64-38-2 (+2050), has locked in his best NFL player props right here.