The Arizona Cardinals visit the New Orleans Saints Sunday to open the 2025 season. Kickoff from Caesars Superdome is at 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Cardinals vs. Saints odds and make our expert NFL picks and predictions for the best bets.

The Cardinals are coming off an 8-9 season in which 8 of their 9 losses were to teams with at least 10 wins. The offensive starting lineup returns almost unchanged, but they added help defensively. LB Josh Sweat, DL Dalvin Tomlinson and DL Calais Campbell signed in free agency and DL Darius Robinson, a first-round pick in 2024, is healthy to start the season.

The Saints begin the Kellen Moore era. Moore was named head coach this offseason, replacing Dennis Allen, and he brought with him defensive coordinator Brandon Staley. QB Derek Carr retired in the offseason and they drafted QB Tyler Shough in the second round of the 2025 draft, but second-year QB Spencer Rattler won the starting job in the preseason.

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Cardinals at Saints odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:56 p.m. ET.

Moneyline (ML): Cardinals -300 (bet $300 to win $100) | Saints +240 (bet $100 to win $240)Against the spread (ATS): Cardinals -6.5 (-110) | Saints +6.5 (-110)Over/Under (O/U): 43 (O: -110 | U: -110)

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Cardinals at Saints key injuries

Cardinals

OL Will Hernandez (knee) outLB Owen Pappoe (quadriceps) questionableDL Dante Stills (heel) questionable

Saints

DB Jordan Howen (oblique) questionableOL Trevor Penning (toe) outDE Chase Young (calf) outCardinals at Saints picks and predictionsPrediction

Cardinals 31, Saints 17

The difference between Cardinals QB Kyler Murray and Rattler, who was 0-6 as a starter last year, is significant.

The Cardinals had the 11th-best offense in 2024 and was seventh in rushing, while the Saints were 30th in total defense and 31st against the run.

The Cardinals should pick up the win, but -300 odds aren’t the value you want, especially in a single bet.

PASS.

The Cardinals were great as an ATS team, going 11-6 ATS last season. They have the offense to put up points, and 5 of their 8 wins were by double digits.

Eight of the Saints’ 12 losses last season were by more than 7 points.

BET CARDINALS -6.5 (-110).

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The Cardinals scored 28 or more points in their last 5 wins and in 6 of their 8 wins last season, so the question is whether the Saints can score enough themselves to get the Over.

With the Cardinals integrating many new starters defensively, and with a high likelihood the Cardinals get out to a big lead and then coast to a win, garbage-time scores are inevitable.

BET OVER 43 (-110).

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