The injury report for the San Francisco 49ers (0-0) heading into their game against the Seattle Seahawks (0-0) includes 17 players. The contest kicks off at 4:05 p.m. ET on Sunday, Sept. 7, at Lumen Field.
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49ers vs Seahawks TV channel & game infoGame day: Sunday, September 7, 2025Game time: 4:05 p.m. ETLocation: Seattle, WashingtonStadium: Lumen FieldTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
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49ers injury reportJordan Watkins | WR (Doubtful)Injury: AnklePractice Status: Limited Participation in PracticeJordan James | RB (Doubtful)Injury: FingerPractice Status: Limited Participation in PracticeChristian McCaffrey | RB (Questionable)Injury: CalfPractice Status: Did Not Participate In Practice2024 Rushing: 50 Attempts | 202 Yards | 0 Touchdowns2024 Receiving: 19 Targets | 15 Receptions | 146 Yards | 0 TouchdownsKalia Davis | DLInjury: GroinPractice Status: Full Participation in Practice2024 Defensive Performance: 0.0 Sacks | 0.0 Tackles for Loss | 12 Tackles | 1 Interception | 1 Pass DefendedYetur Gross-Matos | DLInjury: KneePractice Status: Did Not Participate In Practice2024 Defensive Performance: 4.0 Sacks | 6.0 Tackles for Loss | 19 Tackles | 0 Interceptions | 0 Passes DefendedIsaac Guerendo | RBInjury: ShoulderPractice Status: Full Participation in Practice2024 Rushing: 84 Attempts | 420 Yards | 4 TouchdownsBryce Huff | DLInjury: AnklePractice Status: Full Participation in Practice2024 Defensive Performance: 2.5 Sacks | 3.0 Tackles for Loss | 13 Tackles | 0 Interceptions | 0 Passes DefendedJauan Jennings | WRInjury: CalfPractice Status: Full Participation in Practice2024 Receiving: 113 Targets | 77 Receptions | 975 Yards | 6 TouchdownsMac Jones | QBInjury: KneePractice Status: Full Participation in Practice2024 Passing: 262-for-171 | 1,672 Yards | 8 Touchdowns | 8 Interceptions2024 Rushing: 28 Attempts | 92 Yards | 1 TouchdownSam Okuayinonu | DLInjury: ShoulderPractice Status: Full Participation in Practice2024 Defensive Performance: 3.0 Sacks | 6.0 Tackles for Loss | 35 Tackles | 0 Interceptions | 1 Pass DefendedJason Pinnock | SInjury: HeelPractice Status: Full Participation in Practice2024 Defensive Performance: 3.0 Sacks | 4.0 Tackles for Loss | 85 Tackles | 0 Interceptions | 1 Pass DefendedDominick Puni | OLInjury: KneePractice Status: Full Participation in Practice2024 Season Stats: 3 Games PlayedUpton Stout | CBInjury: CalfPractice Status: Full Participation in PracticeCJ West | DTInjury: KneePractice Status: Full Participation in PracticeMykel Williams | DLInjury: KneePractice Status: Full Participation in PracticeBen Bartch | OLInjury: ElbowPractice Status: Full Participation in Practice2024 Season Stats: 1 Game PlayedTrent Williams | OTInjury: NIR – RestPractice Status: Full Participation in Practice2024 Season Stats: 3 Games Played49ers insightsLast year, the 49ers racked up just 1.3 more points per game (22.9) than the Seahawks surrendered (21.6).In games where San Francisco scored more than 21.6 points last year, it went 6-4 overall and 5-5 against the spread.The Seahawks had a 6-2-1 record against the spread and a 9-0 record overall in games when they gave up fewer than 22.9 points last year.Seattle’s defense allowed 332.7 yards per game last year, 43.6 less than the 376.3-yard average from San Francisco’s offense. San Francisco picked up 6.4 yards per play and Seattle gave up 5.6.49ers vs Seahawks odds
NFL odds courtesy of BetMGM. Odds updated Sunday at 9:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-1.5)Moneyline: 49ers (-120), Seahawks (+100)Total: 43.5 points
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