This affiliate content is not influenced by our advertising relationships, but AP and Data Skrive might earn commissions from our partners’ links in this content.Our computer prediction calls for a relatively comfortable victory (26-19) for the Arizona Cardinals (0-0) over the New Orleans Saints (0-0) on Sunday, Sept. 7 at Caesars Superdome (kickoff at 1 p.m. ET). Our prediction is that the Cardinals will cover the spread (-6.5) and the game will finish over the total (43.5).Cardinals vs. Saints Tickets & Game InfoGame date: Sunday, September 7, 2025Time: 1 p.m. ETVenue: Caesars SuperdomeLocation: New Orleans, LouisianaTV: CBSLive Stream: Watch this game on Fubo (Regional restrictions may apply)Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)Tickets: Get tickets for this game at StubHubCardinals vs. Saints OddsSpread favorite: Cardinals (-6.5)Moneyline: Cardinals (-287), Saints (+232)Total: 43.5 pointsCardinals vs. Saints Score PredictionScore prediction: Arizona Cardinals 26, New Orleans Saints 19Data Skrive’s prediction uses a team strength comparison algorithm, which includes multiple factors such as strength of wins and scoring margin.Cardinals vs. Saints Pick Against the SpreadAgainst the spread prediction: Cardinals (-6.5)Cardinals vs. Saints Moneyline PickMoneyline Pick: Cardinals (-287)Cardinals vs. Saints Over/Under PickOver/Under Pick: Over (43.5)Cardinals vs. Saints Insights (2024 Stats)The Cardinals’ record against the spread last year was 11-6-0.Last year, eight of the Cardinals’ 17 games went over the point total.The Saints’ record against the spread last year was 7-10-0.As 6.5-point underdogs or more, New Orleans went 3-2 against the spread last year.Last season, eight of the Saints’ 17 games went over the point total.

NEW ORLEANS —

This affiliate content is not influenced by our advertising relationships, but AP and Data Skrive might earn commissions from our partners’ links in this content.

Our computer prediction calls for a relatively comfortable victory (26-19) for the Arizona Cardinals (0-0) over the New Orleans Saints (0-0) on Sunday, Sept. 7 at Caesars Superdome (kickoff at 1 p.m. ET). Our prediction is that the Cardinals will cover the spread (-6.5) and the game will finish over the total (43.5).

Cardinals vs. Saints Tickets & Game InfoCardinals vs. Saints OddsSpread favorite: Cardinals (-6.5)Moneyline: Cardinals (-287), Saints (+232)Total: 43.5 points

Cardinals vs. Saints Score Prediction

Score prediction: Arizona Cardinals 26, New Orleans Saints 19

Data Skrive’s prediction uses a team strength comparison algorithm, which includes multiple factors such as strength of wins and scoring margin.

Cardinals vs. Saints Pick Against the Spread

Against the spread prediction: Cardinals (-6.5)

Cardinals vs. Saints Moneyline Pick

Moneyline Pick: Cardinals (-287)

Cardinals vs. Saints Over/Under Pick

Over/Under Pick: Over (43.5)

Cardinals vs. Saints Insights (2024 Stats)The Cardinals’ record against the spread last year was 11-6-0.Last year, eight of the Cardinals’ 17 games went over the point total.The Saints’ record against the spread last year was 7-10-0.As 6.5-point underdogs or more, New Orleans went 3-2 against the spread last year.Last season, eight of the Saints’ 17 games went over the point total.