The Arizona Cardinals open the season Sunday against the New Orleans Saints. They are road favorites by nearly a touchdown. They have high expectations for the 2025 season, while the Saints are largely expected to struggle under rookie head coach Kellen Moore.
What are some predictions and projections for the game?
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Below are expert picks for the Cardinals-Saints game.
Cardinals at Saints expert picks
Jess Root, Cards Wire: Cardinals 31, Saints 17
The Cardinals scored 28 or more points in six of their eight wins last season. They won five times by double digits. They are miles ahead of the Saints in terms of roster talent. Kyler Murray and the offense should have an easy time.
Seth Cox, SB Nation: Cardinals 23, Saints 17
NFL Network experts
All but one of the 10 panelists predict a Cardinals win.
Cardinals-Saints picks
Pick watch
On Pick Watch, 96% of experts have the Cardinals beating the Saints.
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This article originally appeared on Cards Wire: NFL expert picks, Week 1: Cardinals at Saints