NFL Predictions this Week - NFL Week 2 Spreads, Lines, Betting Odds and Predictions for Every Week 2 Game

Baltimore Ravens quarterback Lamar Jackson (8) celebrates with wide receiver Tylan Wallace (16) after a touchdown against the Buffalo Bills during the first half at Highmark Stadium.

Mandatory Credit: Mark Konezny-Imagn Images

It’s quite hard to believe it, but the first week of the NFL season is already behind us. The last of the 16 games this week took place on Monday Night Football as the visiting Minnesota Vikings defeated the Chicago Bears in an NFC North divisional battle.

But NFL fans need not feel too sad because week 2 is just around the corner. There are plenty of exciting games taking place in the upcoming week, starting with the Washington Commanders going up against the Green Bay Packers at Lambeau Field.

Week 2 Prime-Time Games

As was the case in week 1, the upcoming week will also have 4 prime-time games televised nationally. Week 2 begins with the Commanders taking on the Packers on Thursday Night Football (TNF).

Then the Sunday Night Football (SNF) slot will have the Atlanta Falcons going up against the Minnesota Vikings, while there will be two games this time around on the Monday Night Football (MNF) slate.

Day and DateMatchupTime (ET)Broadcast PartnersThursday, September 11Washington Commanders @ Green Bay Packers8:15 p.m.Prime VideoSunday, September 14Atlanta Falcons @ Minnesota Vikings8:20 p.m.NBCMonday, September 15Tampa Bay Buccaneers @ Houston Texans7:00 p.m.ESPNMonday, September 15Los Angeles Chargers @ Las Vegas Raiders10:00 p.m.ESPN NFL Week 2 Spreads

In the 16-game slate for the upcoming week, the Baltimore Ravens are the most favored team as per the NFL point spreads week 2 in their matchup against the Cleveland Browns. The Ravens are favored by a massive 11.5 points over their AFC North rivals.

The Buffalo Bills are the only other team to be favored by 7 points this week. Buffalo plays its divisional rival New York Jets, in week 2. The Cardinals are next as they are 6.5-point favorites over the Panthers.

Moneylines and Betting Odds for Week 2

Once again, the Ravens are huge favorites over the Browns with a moneyline of -770, and the Bills and Cardinals follow as -320 and -310 favorites, respectively. As for the highest over/under for total points, that goes to the Jaguars and Bengals game, which stands at 49.5.

That said, here is a look at the betting odds as per FanDuel for all NFL week 2 matchups, along with the predictions.

Washington Commanders vs Green Bay PackersMoneylineSpreadTotal PointsWashington Commanders +160+3.5 (-108)O 48.5 (-105)Green Bay Packers–188-3.5 (-112)U 48.5 (-115)

Prediction: A tough game to call, but Green Bay’s performance against the Lions earns them gives them the nod, even if slightly.

On to NFL Week 2!!

Thursday Night Football kicks off with the Washington Commanders taking on the Green Bay Packers!

Green Bay -3.5 (-112)
Over/Under 48.5 (-105)

What’s your favorite early bet for the game?? pic.twitter.com/mlMg14vNPb

— Sosa Picks (@SosaPicks) September 9, 2025
Cleveland Browns vs Baltimore Ravens

Both teams lost their opening week matchups, but while the Ravens put up a tough fight and scored 40 on the Bills, the Browns couldn’t even score more than 16 against the Bengals and ended up losing by 1.

MoneylineSpreadTotal PointsCleveland Browns+540+11.5 (-105)O 45.5 (-105)Baltimore Ravens-770-11.5 (-115)U 45.5 (-115)

Prediction: Baltimore’s better quality and top players should get the job done in this divisional matchup.

Los Angeles Rams vs Tennessee Titans

The Rams won a low-scoring game against the Texans in week 1, but the Titans lost by 8 against the Broncos. LA holds the edge in this encounter.

MoneylineSpreadTotal PointsLos Angeles Rams-250-5.5 (-115)O 42.5 (-105)Tennessee Titans+205+5.5 (-105)U 42.5 (-115)

Prediction: It’s hard to choose against the Rams in this game. Titans lack the quality to trouble Los Angeles.

Chicago Bears vs Detroit Lions

Another game in which both teams lost to their divisional opponents in the previous week. Both teams have a lot to prove, but Detroit enters as the favorite in NFL week 2.

MoneylineSpreadTotal PointsChicago Bears+215+5.5 (-110)O 47.5 (-110)Detroit Lions-260-5.5 (-110)U 47.5 (-110)

Prediction: Detroit should get back to winning ways with a win over Chicago.

Buffalo Bills vs New York Jets

The Bills are coming off a tremendous come-from-behind win over the Ravens, and they remain the team to beat in the AFC East. The Jets played well in their loss against the Steelers, giving hope to their fanbase.

MoneylineSpreadTotal PointsBuffalo Bills-320-7 (-105)O 45.5 (-110)New York Jets+250+7 (-115)U 45.5 (-110)

Prediction: With Josh Allen in the form of his life, the Bills should come out on top.

New York Giants vs Dallas Cowboys

Two big rivals go head-to-head in week 2 as the Cowboys take on the Giants. Both teams have started the new season with a loss, but the Cowboys looked well against the Eagles, while the Giants are coming off a tough loss against the Commanders.

MoneylineSpreadTotal PointsNew York Giants+210+5.5 (-106)O 44.5 (-112)Dallas Cowboys-255-5.5 (-114)U 44.5 (-108)

Prediction: Week 1 performances of both teams give the edge to Dallas.

San Francisco 49ers vs New Orleans Saints

The 49ers won against the Seahawks but didn’t look too convincing, while the Saints lost to the Cardinals in their last game. San Francisco has the better team; they just need to pull it together.

MoneylineSpreadTotal PointsSan Francisco 49ers-230-4.5 (-115)O 41.5 (-115)New Orleans Saints+190+4.5 (-105)U 41.5 (-105)

Prediction: San Francisco takes the win over New Orleans.

New England Patriots vs Miami Dolphins

New England fell to the Raiders in their first game, which came as a surprise to some. However, the Miami Dolphins had a forgetful day, losing 33-8 to the Colts. Both will be eyeing a win in week 2.

MoneylineSpreadTotal PointsNew England Patriots+104+1.5 (-108)O 43.5 (-120)Miami Dolphins-122-1.5 (-112)U 43.5 (-102)

Prediction: Patriots to overcome the Dolphins in this AFC East battle.

Jacksonville Jaguars vs Cincinnati Bengals

Jacksonville looked good in week 1, but they played the Panthers, which is not the ideal measuring stick. As for Cincinnati, a lot more is expected from them following their narrow win over the Browns.

MoneylineSpreadTotal PointsJacksonville Jaguars +150+3.5 (-114)O 49.5 (-114)Cincinnati Bengals-178-3.5 (-106)U 49.5 (-106)

Prediction: Cincinnati takes the win over Jacksonville.

Seattle Seahawks vs Pittsburgh Steelers

The Seahawks lost to the 49ers, but the game was close. They will be taking on a Steelers side that looks much better already after Aaron Rodgers’ 4-TD game against the Jets.

MoneylineSpreadTotal PointsSeattle Seahawks+124+2.5 (-104)O 39.5 (-115)Pittsburgh Steelers-144-2.5 (-118)U 39.5 (-105)

Prediction: The Steelers seem more balanced on both sides of the ball and should pull through against Seattle.

Denver Broncos vs Indianapolis Colts

Denver earned a win over Tennessee, but it was anything but pretty. Bo Nix had a horrible game, throwing 2 picks along the way. The Colts, however, had a great day in the office as they dismantled Miami.

MoneylineSpreadTotal PointsDenver Broncos-136+2.5 (-114)O 42.5 (-115)Indianapolis Colts+116-2.5 (-106)U 42.5 (-105)

Prediction: If that was a one-off bad day for Nix, then Denver should get the job done against the Colts.

Carolina Panthers vs Arizona Cardinals

Carolina is still struggling for any momentum, and their loss to the Jaguars shows a lot of work is still required. As for the Cardinals, they won against the Saints, and Carolina could provide a similar test.

MoneylineSpreadTotal PointsCarolina Panthers+250+6.5 (-114)O 44.5 (-102)Arizona Cardinals-310-6.5 (-106)U 44.5 (-120)

Prediction: Cardinals defeat the Panthers to go 2-0 on the season.

Philadelphia Eagles vs Kansas City Chiefs

It’s the Super Bowl rematch as two powerhouses do battle in week 2. The Eagles earned a tough win over the Cowboys, while the Chiefs lost to the Chargers. Kansas City needs a win; otherwise, they will fall to 0-2 quickly.

MoneylineSpreadTotal PointsPhiladelphia Eagles-110-1.5 (-120)O 46.5 (-112)Kansas City Chiefs-106+1.5 (-102)U 46.5 (-108)

Prediction: Playing at home, the Chiefs edge out the Eagles and avenge their Super Bowl loss.

Atlanta Falcons vs Minnesota Vikings

Atlanta played well but lost to the Buccaneers, while the Vikings mounted a late comeback win against the Bears. J.J. McCarthy still has to find his rhythm, but one thing is for sure: he has a calm head on those broad shoulders.

MoneylineSpreadTotal PointsAtlanta Falcons +176+4.5 (-110)O 45.5 (-110)Minnesota Vikings-210-4.5 (-110)U 45.5 (-110)

Prediction: Vikings defense manages to stifle Atlanta as Minnesota takes the win.

Tampa Bay Buccaneers vs Houston Texans

The Buccaneers take on a Texans team that failed to put up double-digit points against the Rams. On paper, Houston is the favorite heading into this one.

MoneylineSpreadTotal PointsTampa Bay Buccaneers+124+2.5 (-102)O 42.5 (-115)Houston Texans-146-2.5 (-120)U 42.5 (-105)

Prediction: Bucs get the win over the Texans in NFL week 2.

Los Angeles Chargers vs Las Vegas Raiders

The Chargers played an excellent game against the Chiefs and came through with a win, while the Raiders defeated the Patriots. Both teams had a productive offseason, but Los Angeles is still the superior team.

MoneylineSpreadTotal PointsLos Angeles Chargers -178-3 (-120)O 46.5 (-115)Las Vegas Raiders+150+3 (-102)U 46.5 (-105)

Prediction: The Chargers defeat the Raiders to remain atop the AFC West standings.

All of the above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: Mark Konezny-Imagn Images

Devavrat Kulkarni

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!

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