Steelers vs. Seahawks prediction, pick, odds for Sunday's NFL Week 2 game

Steelers vs. Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 9:18 p.m.

Moneyline (ML): Pittsburgh -160 (Bet $160 to win $100) | Seattle +135 (Bet $100 to win $135)Against the spread (ATS): Pittsburgh -3 (-110) | Seattle +3 (-110)Over/Under (O/U): 40 (O: -110 | U: -110)Steelers vs. Seahawks betting tips preview

The Seattle Seahawks (0-1) go on the road to take on the Pittsburgh Steelers (1-0) at Acrisure Stadium on Sunday, September 14, 2025, and here are our best bets.

Last time out, the Steelers bested the New York Jets, 34-32. The Seahawks fell short by a final score of 17-13 in their most recent outing, a matchup with the 49ers. In that last outing for the Steelers, Aaron Rodgers completed 22 of 30 passing attempts (73.3%) and totaled 244 yards through the air, completing four touchdown passes. Jaylen Warren had 11 rushing attempts and wound up with 37 yards while also hauling in two receptions for 22 yards and one touchdown. D.K. Metcalf ended the contest with four catches for 83 yards.

For the Seahawks in their last game, Sam Darnold completed 16 of 23 passing attempts (69.6%) and totaled 150 yards through the air. Zach Charbonnet had 12 rushing attempts and finished with 47 yards and one touchdown. Jaxon Smith-Njigba ended the contest with nine catches for 124 yards.

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Steelers vs. Seahawks key injuriesSteelersOT Calvin Anderson (illness) full participation in practiceS DeShon Elliott (knee) did not participate in practiceDT Derrick Harmon (knee) did not participate in practiceLB Nick Herbig (hamstring) full participation in practiceDT Cameron Heyward (NIR – Rest) did not participate in practiceCB Joey Porter Jr. (hamstring) did not participate in practiceLB T.J. Watt (NIR – Rest) full participation in practiceSeahawksWR Jake Bobo (concussion) full participation in practiceS Nick Emmanwori (ankle) did not participate in practiceLB Ernest Jones (shoulder) limited participation in practiceFS Julian Love (groin) limited participation in practiceLB Uchenna Nwosu (knee) full participation in practiceNT Jarran Reed (back) limited participation in practiceCB Devon Witherspoon (knee) did not participate in practiceWR Dareke Young (hamstring) limited participation in practiceSteelers vs. Seahawks prediction

Steelers 22, Seahawks 21

Moneyline pick: Steelers -160The Steelers have an implied moneyline win probability of 61.5% in this game.Pittsburgh was favored on the moneyline eight total times last season. They finished 5-3 in those games.The Steelers finished 3-1 last year (winning 75% of their games) when playing as a moneyline favorite of -160 or shorter.Last season, Seattle was the underdog 11 times and won five, or 45.5%, of those games.The Seahawks were 1-2 last season when entering a game as the underdog by +135 or more on the moneyline.Pick ATS: Seahawks (+3)Pittsburgh had 11 wins in 17 games against the spread last season.The Steelers’ ATS record as 3-point favorites or greater was 3-1 last year.Seattle’s record against the spread last year was 6-10-1.The Seahawks went 3-4 as underdogs of 3 points or more last season.Pick OU: Over (40)In 10 of 17 games last season, the Steelers and their opponents combined to score more than 40 points.The Seahawks’ games last season had a combined scoring total higher than 40 points in 13 of 17 outings.The two teams combined to score 44.5 points per game last season, 4.5 more points than the total for this matchup.Opponents of these two teams scored 42 combined points per game last season, two more than the over/under for this matchup.Steelers matchups last season had an average point total of 41.9, 1.9 more points than this game’s over/under.The Seahawks had a 44.7-point average over/under in their contests last year, 4.7 more points than the point total for this game.

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Steelers vs. Seahawks prediction, pick, odds for Sunday’s NFL Week 2 game

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