The Arizona Cardinals (1-0) are less than a touchdown favorite (-6.5) on Sunday, September 14, 2025 against the Carolina Panthers (0-1).
Cardinals vs. Panthers game infoGame day: Sunday, September 14, 2025Game time: 4:05 p.m. ETTV channel: CBSLocation: Glendale, ArizonaStadium: State Farm StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)
Watch Arizona Cardinals vs. Carolina Panthers on Fubo! (Regional restrictions may apply)
Cardinals vs. Panthers odds & betting linesSpread favorite: Arizona (-6.5)Moneyline: Arizona (-304), Carolina (+245)Total: 44.5 points
NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 2:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Cardinals vs. Panthers recent matchupsOver the past four matchups between Arizona and Carolina, the Panthers are 3-1.Carolina scored 124 points in those four matchups, while Arizona posted 86.Cardinals vs. Panthers 2024 betting insightsArizona compiled an 11-6-0 ATS record last year.Carolina put together an 8-9-0 record against the spread last year.Arizona’s 17 games last season went over this contest’s total of 44.5 points 11 times.Carolina and its opponents combined to score more than 44.5 points in 12 of 17 games last season.Cardinals 2024 scoring insightsThe Cardinals put up 26.7 points per game at home last year, higher than their 20.0 average on the road.On defense, Arizona’s average at home, 19.2 points conceded, was lower than its average on the road, 25.8.The Cardinals scored 24.2 points per game in divisional contests last year, which was a little better than their 23.2 average versus the rest of the league.The Cardinals averaged fewer points conceded in division games (19.3) than against the rest of the league (23.9).Arizona ranks 14th in scoring offense over the last three games (20.0 points per game), but it ranks fifth-best in scoring defense during that stretch (13.0 points per game allowed).Panthers 2024 scoring insightsThe Panthers’ scoring average at home last season, 21.1 points per game, was better than their average on the road, 18.9.Defensively, Carolina’s average at home, 28.1 points conceded, was better than its average away, 35.1.The Panthers scored 22.3 points per game in the division last season, which was better than their mark in non-division games of 18.8.The Panthers averaged more points allowed in division games (36.5) than outside the division (28.6).Carolina is fourth-worst in the NFL in points scored for the past three games (10.0 per game) and 24th in points conceded (26.0).Cardinals injury reportCardinals:
Jon Gaines II: Full Participation in Practice (Thumb),
Blake Gillikin: Limited Participation in Practice (Back),
Will Hernandez: Limited Participation in Practice (Knee),
Kelvin Beachum: Full Participation in Practice (Rest),
Cody Simon: Did Not Participate In Practice (Concussion),
Tip Reiman: Did Not Participate In Practice (Foot)Panthers injury reportPanthers:
Ikem Ekwonu: Limited Participation in Practice (Illness),
Tershawn Wharton: Did Not Participate In Practice (Hamstring),
Akayleb Evans: Limited Participation in Practice (Illness),
A’Shawn Robinson: Full Participation in Practice (Groin),
Damien Lewis: Full Participation in Practice (Shoulder),
Robert Hunt: Full Participation in Practice (Foot),
Hunter Renfrow: Limited Participation in Practice (Ribs),
Patrick Jones II: Limited Participation in Practice (Ankle)
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