Broncos at Colts odds, picks and predictions

The Denver Broncos (1-0) and the Indianapolis Colts (1-0) meet Sunday. Kickoff from Lucas Oil Stadium in Indianapolis, Indiana, is scheduled for 4:05 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Broncos vs. Colts odds and make our expert NFL picks and predictions for the best bets.

The Broncos are coming off a 20-12 home win over the Tennessee Titans Sept. 7, but failed to cover as 9-point favorites as the Under (42.5) hit. Denver’s defense sacked rookie QB Cam Ward 6 times and held Tennessee to 2.4 yards per play. QB Bo Nix went 25-of-40 for 176 yards with 1 TD and 2 INTs.

The Colts routed the Miami Dolphins 33-8 in Week 1, covering as 1-point home favorites with the Under (46.5) cashing. QB Daniel Jones completed 22-of-29 passes for 272 yards and 1 TD and added 2 rushing scores, ending Indianapolis’ 11-year opening-day winless streak — the longest active streak in the NFL. WR Michael Pittman Jr. had 8 receptions for 60 yards and a TD, and RB Jonathan Taylor ran for 71 yards on 18 carries.

In their last meeting (Dec. 15, 2024), the Broncos covered as 4.5-point home favorites in a 31-13 win over the Colts as the Over (43.5) hit. Denver had 5 takeaways, including a 50-yard defensive touchdown by LB Nik Bonitto off a fumble recovery.

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Broncos at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:13 p.m. ET.

Moneyline (ML): Broncos -125 (bet $125 to win $100) | Colts +105 (bet $100 to win $105)Against the spread (ATS): Broncos -2.5 (-110) | Colts +2.5 (-120)Over/Under (O/U): 43.5 (O: -105 | U: -115)

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Broncos at Colts key injuries

Broncos

LB Dre Greenlaw (quad) out

Colts

DE Laiatu Latu (hamstring) questionableCB Charvarius Ward (concussion) outBroncos at Colts picks and predictionsPrediction

Broncos 24, Colts 21

DENVER (-125) still being favored on the road after the Colts routed the Dolphins in Week 1 is a positive sign for Broncos bettors.

The line was Denver -185 Sept. 7 before money started pouring in on Indianapolis at 6:39 p.m. ET. Moving from -185 to -125 seems like an overreaction after just 1 game, especially since the Broncos will come in hyper-focused after coach Sean Payton said he has “to be a lot better” following the offense’s struggles in Week 1.

BET BRONCOS (-125).

Denver -2.5 (-120) isn’t a bad bet, but Broncos ML is the safer play.

PASS on the spread.

The Broncos went 11-6 to the Over last season — and 1 of those Unders came in a 38-0 Week 18 win over the Kansas City Chiefs, who rested several key starters. Payton expects the offense to improve in Week 2, even though the line has dropped from 44.5 to 43.5.

There are 2 ways to attack this: BET OVER 43.5 (-105) or BRONCOS TOTAL POINTS OVER 21.5 (-125). Both bets look solid, and the former becomes an even stronger play if Jones doesn’t fall off too hard after an impressive debut.

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Broncos at Colts odds, picks and predictions

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