Check out the injury report for the San Francisco 49ers (1-0), which currently includes 12 players, as the 49ers ready for their matchup against the New Orleans Saints (0-1) at Caesars Superdome, on Sunday, Sept. 14 at 1 p.m. ET.
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49ers vs Saints TV channel & game infoGame day: Sunday, September 14, 2025Game time: 1 p.m. ETLocation: New Orleans, LouisianaStadium: Caesars SuperdomeTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. New Orleans Saints on Fubo! (Regional restrictions may apply)
49ers injury reportBrock Purdy | QB (Out)Injury: ShoulderPractice Status: Did Not Participate In Practice2025 Passing: 35-for-26 | 277 Yards | 2 Touchdowns | 2 Interceptions2025 Rushing: 5 Attempts | 17 Yards | 0 TouchdownsJauan Jennings | WR (Questionable)Injury: ShoulderPractice Status: Limited Participation in Practice2025 Receiving Stats: 5 Targets | 2 Receptions | 16 Yards | 0 TouchdownsTrent Williams | OT (Questionable)Injury: KneePractice Status: Limited Participation in Practice2025 Season Stats: 1 Games PlayedChristian McCaffrey | RBInjury: CalfPractice Status: Full Participation in Practice2025 Rushing: 22 Attempts | 69 Yards | 0 Touchdowns2025 Receiving Stats: 10 Targets | 9 Receptions | 73 Yards | 0 TouchdownsMac Jones | QBInjury: KneePractice Status: Full Participation in Practice2024 Passing: 262-for-171 | 1,672 Yards | 8 Touchdowns | 8 Interceptions2024 Rushing: 28 Attempts | 92 Yards | 1 TouchdownJordan James | RBInjury: FingerPractice Status: Full Participation in PracticeNick Bosa | DLInjury: RestPractice Status: Full Participation in Practice2025 Defensive Stats: 1.0 Sack | 3.0 Tackles for Loss | 6 Tackles | 0 Interceptions | 0 Passes DefendedLuke Gifford | LBInjury: KneePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 3 Tackles | 0 Interceptions | 0 Passes DefendedBen Bartch | OLInjury: KneePractice Status: Full Participation in Practice2024 Season Stats: 1 Game PlayedJordan Watkins | WRInjury: AnklePractice Status: Full Participation in PracticeDominick Puni | OLInjury: KneePractice Status: Full Participation in Practice2024 Season Stats: 3 Games PlayedYetur Gross-Matos | DLInjury: KneePractice Status: Limited Participation in Practice2025 Season Stats: 1 Games Played49ers insightsThe 49ers put up 22.9 points per game last year, comparable to the 23.4 per outing the Saints gave up.In games where San Francisco scored more than 23.4 points last season, it was 5-3 overall and 5-3 against the spread.When the Saints limited opponents to less than 22.9 points last year, they had a 5-3 record against the spread and a 5-3 record overall.New Orleans’ defense allowed 379.9 yards per game last year, just 3.6 yards more than the 376.3 San Francisco’s offense averaged. San Francisco picked up 6.4 yards per play, while New Orleans allowed 6.0.49ers vs Saints odds
NFL odds courtesy of BetMGM. Odds updated Sunday at 1:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-3)Moneyline: 49ers (-157), Saints (+133)Total: 40.5 points
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