The Kansas City Chiefs enter Week 3 at 0–2 and will try to get on track when they face the New York Giants on Sunday Night Football at MetLife Stadium. The Giants, who are also winless, continue to lean on veteran quarterback Russell Wilson as rookie Jaxson Dart develops behind him. Neither team has looked sharp through the first two weeks, setting the stage for a matchup more about survival than statement wins.

Oddsmakers still give Kansas City the edge, listing the Chiefs as 6.5-point favorites with a 71% win probability from Dimers.com’s predictive model. The Giants, however, are projected to keep things competitive, with the model assigning them a 57% chance to cover the spread. The total sits at 43.5 points, suggesting a modest-scoring game in primetime.

Dimers’ simulations forecast a final score of 24-19, pointing toward a narrow Kansas City win that avoids a disastrous 0–3 start. For the Giants, the task is straightforward: protect Wilson, lean on the run game, and keep things close enough for their defense to have a chance late. Kickoff is set for Sunday, September 21 at 8:20 p.m. ET.

Chiefs vs. Giants betting preview

Explore the interactive widget below to discover the latest spread, over/under, and moneyline odds and probabilities for the Chiefs-Giants game at MetLife Stadium.

This prediction and best bet for the NFL matchup between the Chiefs and Giants is from Dimers.com, a reliable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Chiefs vs. Giants NFL game.

Teams: Kansas City Chiefs vs. New York GiantsDate: Sunday, September 21, 2025Kickoff: 8:20 p.m. ETLocation: MetLife StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL clash between the Chiefs and Giants.

Spread: Chiefs -6.5 (-110), Giants +6.5 (-110)Moneyline: Chiefs -290, Giants +235Total: Over/Under 43.5 (-110/-110)

The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Chiefs vs. Giants

Using advanced data analysis and computer power, the experts at Dimers have performed 10,000 simulations of the Chiefs vs. Giants matchup.

According to Dimers’ popular predictive analytics model, the Chiefs are more likely to defeat the Giants at MetLife Stadium. This prediction is based on the model giving the Chiefs a 71% chance of winning the game.

Furthermore, Dimers predicts that the Giants (+6.5) have a 57% chance of covering the spread, while the over/under total of 43.5 points is considered an equal 50-50 chance of hitting.

As always, these predictions and probabilities are correct at the time of publication but are subject to potential changes.

Chiefs vs. Giants best bet

Our top pick for the Chiefs vs. Giants Week 3 NFL matchup is to bet on the Giants +6.5 (-110).

This expert betting advice is formulated through comprehensive modeling and valuable betting intelligence, designed to bring you the best possible plays.

Score prediction for Chiefs vs. Giants

Dimers’ predicted final score for the Kansas City vs. NY Giants game on Sunday has the Chiefs winning 24-19.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL Week 3: Chiefs vs. Giants

Get ready for Sunday’s action between the Chiefs and Giants in Week 3 of the NFL season at MetLife Stadium, which is scheduled to start at 8:20 p.m. ET. We emphasize that all of the NFL predictions and NFL best bets on this page are derived from 10,000 data-driven simulations of the Chiefs vs. Giants game, and they are accurate at the time of publishing. They aim to assist you make better decisions when placing bets at online sportsbooks.

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