The Buffalo Bills (2-0) are considered 12.5-point favorites when they host the Miami Dolphins (0-2) in an AFC East matchup on Thursday, September 18, 2025 at Highmark Stadium. The over/under is set at 49.5 points for the outing.
Are you looking to place a parlay bet on this game? See insights, including first to score and prop bets for the top players, int the article below.
Bills vs. Dolphins game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 1:41 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread: Bills -12.5 (-110 to cover)Moneylines: Bills -800, Dolphins +575Total: 49.5 points (Over: -110, Under: -110)Pick ATS: Bills (-12.5)Pick OU: Under (49.5)Prediction:
Bills 32 – Dolphins 15First TD odds and insights
First TD odds: Bills -275, Dolphins +195
The Bills have scored the opening touchdown two times this season out of two games played.In those two games when Buffalo scored the first touchdown, it threw for one and rushed for one.Looking at just first quarters, the Bills have scored two touchdowns, the second-most of all teams this season.The Dolphins have not scored the opening touchdown in any of their two games this season.In the first quarter, the Dolphins have failed to score a touchdown this year.
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Josh Allen player propsPassing yard prop: Over/under 234.5 yardsRushing yard prop: Over/under 26.5 yardsCompared to his 234.5-yard passing yards prop total for this matchup, Josh Allen is recording more yards per game (271.0) so far this season.Allen has gone over his passing yard total once this season (50.0% of total opportunities).In one of two games this year, Allen has thrown a touchdown pass — and he threw multiple TD passes in that game.James Cook player propsRushing yard prop: Over/under 66.5 yardsReceiving yard prop: Over/under 10.5 yardsJames Cook averages 88.0 rushing yards per game this season, which outpaces Thursday’s prop total of 66.5 yards.Cook hit his rushing yards over once in two games played this season.Cook has rushing touchdowns in all two games this season, including multiple TDs once.De’Von Achane player propsRushing yard prop: Over/under 52.5 yardsReceiving yard prop: Over/under 37.5 yardsThursday’s rushing yards over/under for De’Von Achane is set at 52.5 yards. That’s 10.0 more than his season average of 42.5.Achane has fallen short of his rushing yards prop bet total in each of his two games played this season.Achane has not found paydirt on the ground this year in two games.Tua Tagovailoa player propsPassing yard prop: Over/under 234.5 yardsTua Tagovailoa’s per-game passing yardage average this season (214.5) is 20.0 passing yards less than Thursday’s over/under.Tagovailoa has gone over his passing yard total once in two games with a prop available.Tagovailoa has a passing touchdown in all two games this year, with multiple passing TDs in one of them.