The Houston Texans (0-2) visit the Jacksonville Jaguars (1-1) at EverBank Stadium in Jacksonville for a Week 3 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, September 21, including live updated odds and injury report news.

Jaguars vs. Texans live odds, moneyline, over/under

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Jaguars vs. Texans picks against the spread

Jordan Mendoza: Jacksonville Jaguars (-1)

Both teams are coming off heartbreaking losses in Week 2 and need to right the ship. It’s hard to imagine the Texans moving to 0-3, but Jacksonville’s offense is more trustworthy heading into this matchup.

Jon Hoefling: Jacksonville Jaguars (-1)

After a bit of a meltdown against Cincinnati, I’m buying the dip on Jacksonville. At some point, Travis Hunter and/or Brian Thomas Jr. is going to show up, and I trust Liam Coen to take advantage of Houston’s atrocious pass blocking.

Tyler Dragon: Houston Texans (+1)

This might be a must win for the 0-2 Texans. The Jaguars let Jake Browning cook on them last week. That means C.J. Stroud should have a field day against Jacksonville.

Christopher Bumbaca: Jacksonville Jaguars (-1)

It’s tough to picture the Texans starting 0-3 but the offensive line really may be that bad (and the schedule that unforgiving). And I like the combination of the Jaguars’ offense looking better and Jacksonville being at home.

Blake Schuster: Houston Texans (+1)

This almost qualifies as a get-right game for Houston, which had a tough draw opening the season against the Rams and Buccaneers – two tough teams almost always overlooked. The 0-2 Texans are only a combined six points from staring 2-0.

Lorenzo Reyes: Jacksonville Jaguars (-1)

Houston has simply been so underwhelming to start this season, and the Jaguars have been surprisingly dominant on the ground. At home, with the line essentially a pick ’em, I think Jacksonville is in a great spot here.

Jaguars vs. Texans updated injury reportNFL Week 3 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 2 Record2025 RecordChris Bumbaca10-617-13-2Tyler Dragon11-516-14-2Jon Hoefling10-616-14-2Lorenzo Reyes9-716-14-2Blake Schuster9-716-14-2Jordan Mendoza9-715-15-2Super Bowl 60 updated odds