The Detroit Lions (1-1) visit the Baltimore Ravens (1-1) at M&T Bank Stadium in Baltimore for a Week 3 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Monday, September 22, including live updated odds and injury report news.

Ravens vs. Lions live odds, moneyline, over/under

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Ravens vs. Lions picks against the spread

Jordan Mendoza: Detroit Lions (+5.5)

The Lions are just fine as they head into what could be a spectacular game on Monday night. Given Baltimore’s history in holding onto leads, this one goes to the final minute.

Jon Hoefling: Baltimore Ravens (-5.5)

The best time for a letdown loss is right after a huge, emotional win. The Detroit Lions had a massive bounce-back effort in Week 2, but they’re riding a little too high while Derrick Henry is looking to avenge himself after his poor performance last week.

Tyler Dragon: Baltimore Ravens (-5.5)

The Week 3 finale is the Game of the Week. Lamar Jackson puts on an MVP performance, and Derrick Henry bounces back after being contained last week.

Christopher Bumbaca: Detroit Lions (+5.5)

The Ravens’ prime-time record at home is ridiculous so they are definitely winning this game. But that number felt a little too big for the Lions.

Blake Schuster: Baltimore Ravens (-5.5)

The Lions have to be feeling great after hanging 50 on their old offensive coordinator last week. They’ll come back down to Earth against a true Super Bowl contender on Monday Night Football.

Lorenzo Reyes: Detroit Lions (+5.5)

Baltimore tends to let teams back in games. The Lions are formidable and may even win outright. I think this is great value for a Detroit team that may have course corrected after a Week 1 dud.

Ravens vs. Lions updated injury reportNFL Week 3 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 2 Record2025 RecordChris Bumbaca10-617-13-2Tyler Dragon11-516-14-2Jon Hoefling10-616-14-2Lorenzo Reyes9-716-14-2Blake Schuster9-716-14-2Jordan Mendoza9-715-15-2Super Bowl 60 updated odds