The New Orleans Saints (0-2) visit the Seattle Seahawks (1-1) at Lumen Field in Seattle for a Week 3 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, September 21, including live updated odds and injury report news.

Seahawks vs. Saints live odds, moneyline, over/under

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Seahawks vs. Saints picks against the spread

Jordan Mendoza: New Orleans Saints (+7.5)

The Saints have looked somewhat better than predicted, but they’re still 0-2. They’ll be 0-3 going into a hostile environment, but they hang around in Seattle.

Jon Hoefling: Seattle Seahawks (-7.5)

When you can’t even cover the spread against a 49ers team missing several key players, you know the Saints are in a bad spot. Give me the Seahawks in a game that should offer massive performances from both Kenneth Walker and Zach Charbonnet.

Tyler Dragon: Seattle Seahawks (-7.5)

It’s getting late early in New Orleans. When will the Saints name Tyler Shough starter? Do the Saints wait until their Week 11 bye week? The Seahawks had a nice win in Pittsburgh in Week 2.

Christopher Bumbaca: Seattle Seahawks (-7.5)

The Saints will eventually win a game, but it won’t come on the road against a Mike Macdonald defense that is off to a good start. Could Seattle have another two-possession victory?

Blake Schuster: Seattle Seahawks (-7.5)

The Saints could barely hang with a banged up 49ers team in the Superdome. No chance I can trust them to cover in Seattle.

Lorenzo Reyes: New Orleans Saints (+7.5)

The Saints have a young team that is in a rebuild, but they haven’t quite been blown out thus far. And while the Seahawks did stomp the Steelers, this line is a bit too rich for me, especially given that Seattle is far from a known commodity, in its own right.

Seahawks vs. Saints updated injury reportNFL Week 3 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 2 Record2025 RecordChris Bumbaca10-617-13-2Tyler Dragon11-516-14-2Jon Hoefling10-616-14-2Lorenzo Reyes9-716-14-2Blake Schuster9-716-14-2Jordan Mendoza9-715-15-2Super Bowl 60 updated odds