The Indianapolis Colts will face off against the Tennessee Titans in a crucial Week 3 NFL matchup at Nissan Stadium on Sunday, September 21, 2025. Both teams are looking to make an impact early in the season, and this game could be pivotal in shaping their standings in the AFC. The Colts, with a 67% chance of victory according to Dimers’ predictive model, are favored to win the game, and they will look to leverage their strengths, including standout running back Jonathan Taylor, to continue their strong start. The Titans, however, are coming off a tough battle and will aim to pull off an upset in front of their home crowd.

The Colts enter this game with the advantage, thanks to their well-rounded team led by quarterback Daniel Jones, who has been showing steady growth since joining the squad. They will be looking to improve on their 2-0 start, relying on their offensive balance and a defense that can contain the Titans’ playmakers. With the Titans facing a difficult matchup against the Colts’ potent offense, the pressure will be on Tennessee’s quarterback, Cam Ward, to keep the Titans competitive, especially with their shaky injury status and limited depth in key areas.

Betting odds show the Colts as 3.5-point favorites, with the total set at 43.5 points, reflecting the expected close nature of the game. Dimers’ model projects a final score of 24-19 in favor of the Colts, but with the Titans’ ability to perform in critical situations, this game has all the makings of a tight contest. Whether the Colts can cover the spread and continue their early-season momentum or the Titans rise to the occasion and challenge the odds, this Week 3 game promises to be an exciting matchup for NFL fans.

Colts vs. Titans betting preview

Explore the interactive widget below to discover the current spread, total, and moneyline betting odds and probabilities for the Colts-Titans matchup at Nissan Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Colts and Titans is from Dimers.com, a reliable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Colts vs. Titans NFL game.

Teams: Indianapolis Colts vs. Tennessee TitansDate: Sunday, September 21, 2025Kickoff: 1 p.m. ETLocation: Nissan StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

Odds for the key markets in the Colts-Titans NFL contest.

Spread: Colts -3.5 (-115), Titans +3.5 (-105)Moneyline: Colts -198, Titans +176Total: Over/Under 43.5 (-106/-110)

The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Colts vs. Titans

Utilizing advanced data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday’s Colts vs. Titans game.

According to Dimers’ renowned predictive analytics model, the Colts are more likely to defeat the Titans at Nissan Stadium. This prediction is based on the model giving the Colts a 67% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the Colts (-3.5) have a 54% chance of covering the spread, while the 43.5-point over/under is considered an equal 50-50 chance of hitting.

As always, these predictions and probabilities are correct at the time of publication but are subject to change.

Colts vs. Titans best bet

Our top pick for the Colts vs. Titans Week 3 NFL matchup is to bet on the Colts moneyline (-198).

This expert betting advice is formulated through cutting-edge modeling and valuable wagering intelligence, designed to deliver you the best possible plays.

Score prediction for Colts vs. Titans

Dimers’ projected final score for the Indianapolis vs. Tennessee game on Sunday has the Colts winning 24-19.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL prop picks are a common way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Colts and Titans, as well as projected player stats.

Indianapolis ColtsFirst touchdown scorer predictionsJonathan Taylor: 16.4% probabilityTyler Warren: 6.8% probabilityDaniel Jones: 6.6% probabilityAnytime touchdown predictionsJonathan Taylor: 57.6% probabilityTyler Warren: 29.9% probabilityDaniel Jones: 29.1% probabilityProjected box score leadersQB passing yards: Daniel Jones, 214 yardsReceiving yards: Michael Pittman, 50 yardsRushing yards: Jonathan Taylor, 87 yardsTennessee TitansFirst touchdown scorer predictionsTony Pollard: 11.0% probabilityElic Ayomanor: 10.1% probabilityCalvin Ridley: 6.8% probabilityAnytime touchdown predictionsTony Pollard: 43.0% probabilityElic Ayomanor: 40.4% probabilityCalvin Ridley: 29.5% probabilityProjected box score leadersQB passing yards: Cam Ward, 207 yardsReceiving yards: Calvin Ridley, 56 yardsRushing yards: Tony Pollard, 79 yardsNFL Week 3: Colts vs. Titans

Get ready for Sunday’s matchup between the Colts and Titans in Week 3 of the National Football League season at Nissan Stadium, which is scheduled to start at 1 p.m. ET. We emphasize that all of the NFL best bets and NFL predictions on this page are derived from 10,000 data-driven simulations of the Colts vs. Titans game, and they are accurate at the time of publishing. They are intended to assist you make more informed choices when placing bets at online sportsbooks.

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