Week 3 of the 2025 NFL regular season is set to begin in less than 24 hours.
The third week of the 2025 NFL regular season is scheduled to start on Thursday night, with an AFC East matchup. The Buffalo Bills are scheduled to host the Miami Dolphins on Amazon Prime’s Thursday Night Football. The Dolphins, who entered the 2025 season needing to show signs of improvement, have started off the year at 0-2. The Bills, meanwhile, are 2-0 on the season, topping the AFC rival Ravens in Week 1.
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Thursday night, with Al Michaels and Kirk Herbstreit on the call, the Bills and the Dolphins will square off at Highmark Stadium in Upstate New York.
Aug 23, 2025; Tampa, Florida, USA; Buffalo Bills quarterback Josh Allen (17) warms up before a game against the Tampa Bay Buccaneers at Raymond James Stadium. Mandatory Credit: Nathan Ray Seebeck-Imagn Images
ESPN’s computer model, the Football Power Index, likes the Bills to take down the Dolphins in this one.
The Football Power Index pick: Bills over Dolphins.
ESPN’s computer model is giving the Bills a 76.4 percent chance to win the game, while it gives the Dolphins just a 23.4 percent chance to win the game.
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How to watch Bills vs. Dolphins
Kickoff time: 8:15 p.m. E.T.
Where to watch: Amazon Prime Video
Announcers: Al Michaels, Kirk Herbstreit, Kaylee Hartung
Betting line: Bills -10.5
This story was originally reported by The Spun on Sep 18, 2025, where it first appeared in the NFL section. Add The Spun as a Preferred Source by clicking here.