The New York Giants (0-2) will attempt to defy oddsmakers when they play the Kansas City Chiefs (0-2) on Sunday, September 21, 2025 as 6.5-point underdogs.

Chiefs vs. Giants game info

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Chiefs vs. Giants odds & betting linesSpread favorite: Kansas City (-6.5)Moneyline: Kansas City (-299), New York (+241)Total: 45 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Chiefs vs. Giants recent matchupsThese two teams have played evenly over the last two matchups, with the series tied 1-1 over that span.Kansas City and New York each totaled 29 points in those two contests.Chiefs vs. Giants betting insightsKansas City, through two games with a spread this season, has gone 0-2-0 against the spread. The Chiefs lost the only game they played as the moneyline favorite this season. New York has a single win against the spread this season (1-1-0). This will be the third game this year the Giants are an underdog on the moneyline. They lost both of the games.Chiefs scoring insightsThe Chiefs rank 24th in scoring offense (19.0 points per game) and 19th in scoring defense (23.5 points per game surrendered) over their last three games.Giants scoring insightsIn their past three games, the Giants are scoring 21.5 points per game (18th in league), and allowing 30.5 (27th).Chiefs injury reportChiefs:
Drue Tranquill: Full Participation in Practice (Knee),
Jawaan Taylor: Limited Participation in Practice (Knee),
Charles Omenihu: Full Participation in Practice (Hand),
Patrick Mahomes: Full Participation in Practice (Wrist),
Ashton Gillotte: Full Participation in Practice (Elbow),
Marquise Brown: Full Participation in Practice (Ankle),
Josh Simmons: Full Participation in Practice (Illness),
Xavier Worthy: Limited Participation in Practice (Shoulder),
Jalen Royals: Full Participation in Practice (Knee),
Kristian Fulton: Did Not Participate In Practice (Ankle),
Michael Danna: Did Not Participate In Practice (Quad)Giants injury reportGiants:
Cam Skattebo: Full Participation in Practice (Ankle),
Roy Robertson-Harris: Full Participation in Practice (Knee),
Tyrone Tracy Jr.: Limited Participation in Practice (Calf),
Andrew Thomas: Limited Participation in Practice (Foot),
Darius Slayton: Limited Participation in Practice (Groin),
John Michael Schmitz: Limited Participation in Practice (Toe),
Jon Runyan Jr.: Limited Participation in Practice (Back),
Wan’Dale Robinson: Limited Participation in Practice (Foot),
Rakeem Nunez-Roches: Limited Participation in Practice (Foot),
Gunner Olszewski: Limited Participation in Practice (Back),
Darius Muasau: Did Not Participate In Practice (Concussion),
Chauncey Golston: Did Not Participate In Practice (Ankle),
Demetrius Flannigan-Fowles: Limited Participation in Practice (Calf)

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