The New Orleans Saints (0-2) will attempt to defy oddsmakers when they square off against the Seattle Seahawks (1-1) on Sunday, September 21, 2025 as a 7.5-point underdog.
Seahawks vs. Saints game infoGame day: Sunday, September 21, 2025Game time: 4:05 p.m. ETTV channel: CBSLocation: Seattle, WashingtonStadium: Lumen FieldLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Seahawks vs. Saints odds & betting linesSpread favorite: Seattle (-7.5)Moneyline: Seattle (-391), New Orleans (+308)Total: 41.5 points
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Seahawks vs. Saints recent matchupsOver the past three matchups between Seattle and New Orleans, the Saints are 3-0.New Orleans has had the upper hand scoring in those three matchups, totaling 85 points while Seattle put up 69.Seahawks vs. Saints betting insightsSeattle has won once against the spread so far this season (1-1-0). The Seahawks have not been the moneyline favorite so far this season. New Orleans, in two games with a set spread this season, is 0-2-0 against the spread. This will be the third game this year the Saints are the moneyline underdog. They lost both of the games.Seahawks scoring insightsOn the offensive side of the ball, the Seahawks have put up 22.0 points per game over their last three games (16th-ranked). Meanwhile, they have allowed an average of 17.0 points on defense over that timeframe (seventh-ranked).Saints scoring insightsIn their past three games, the Saints are scoring 17.0 points per game (26th in NFL), and allowing 23.0 (17th).Seahawks injury reportSeahawks:
Devon Witherspoon: Did Not Participate In Practice (Knee),
Abraham Lucas: Full Participation in Practice (Elbow),
Julian Love: Did Not Participate In Practice (Hamstring),
Ernest Jones: Full Participation in Practice (Shoulder),
Josh Jobe: Full Participation in Practice (Knee),
Tory Horton: Limited Participation in Practice (Groin),
Derick Hall: Full Participation in Practice (Hip),
Nick Emmanwori: Did Not Participate In Practice (Ankle),
Zach Charbonnet: Did Not Participate In Practice (Foot)Saints injury reportSaints:
Trey Palmer: Did Not Participate In Practice (Hamstring),
Chase Young: Did Not Participate In Practice (Calf),
Dillon Radunz: Did Not Participate In Practice (Toe),
Taliese Fuaga: Did Not Participate In Practice (Knee),
Devaughn Vele: Limited Participation in Practice (Hip),
Trevor Penning: Limited Participation in Practice (Toe)
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