The Indianapolis Colts (2-0) visit the Tennessee Titans (0-2) on Sunday, September 21, 2025 in matchup between AFC South opponents at Nissan Stadium. Tennessee is a 3.5-point underdog.

Colts vs. Titans game infoGame day: Sunday, September 21, 2025Game time: 1 p.m. ETTV channel: CBSLocation: Nashville, TennesseeStadium: Nissan StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

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Colts vs. Titans odds & betting linesSpread favorite: Indianapolis (-3.5)Moneyline: Indianapolis (-206), Tennessee (+169)Total: 43.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Colts vs. Titans recent matchupsIndianapolis has gone 4-1 versus Tennessee over the last five matchups between the two teams.The Colts and Titans haven’t gone over the total in any of their past five matchups, but Indianapolis is 4-1 against the spread in those games.Indianapolis has had the scoring advantage in those five matchups, totaling 122 points against Tennessee’s 110.Colts vs. Titans betting insightsIndianapolis, in two games with a spread this season, has not lost (2-0-0) against the spread. In one game as a moneyline favorite, the Colts won. Tennessee has won once against the spread so far this season (1-1-0). This is the third game this year the Titans are the moneyline underdog. They lost both of the games.Colts scoring insightsOn offense, the Colts have been making things happen over the previous three contests, putting up 31.0 points per game (fourth-best). They rank 11th over the last three games on defense (18.0 points per game allowed).Titans scoring insightsIn their past three games, the Titans are scoring 15.5 points per game (third-worst in NFL) and conceding 26.5 per game (23rd).Colts injury reportColts:
Tyler Warren: Limited Participation in Practice (Toe),
Charvarius Ward: Full Participation in Practice (Concussion),
Grover Stewart: Did Not Participate In Practice (NIR – Rest),
Bernhard Raimann: Limited Participation in Practice (Illness),
Laiatu Latu: Full Participation in Practice (Hamstring),
Tyler Goodson: Full Participation in Practice (Elbow),
Josh Downs: Full Participation in Practice (Ankle),
Austin Ajiake: Full Participation in Practice (Throat),
Joe Bachie: Did Not Participate In Practice (Quadricep)Titans injury reportTitans:
Kevin Zeitler: Limited Participation in Practice (Biceps),
Kevin Winston Jr.: Limited Participation in Practice (Hamstring),
T’Vondre Sweat: Limited Participation in Practice (Ankle),
L’Jarius Sneed: Did Not Participate In Practice (Back),
Bryce Oliver: Did Not Participate In Practice (Knee),
Kalel Mullings: Limited Participation in Practice (Ankle),
JC Latham: Did Not Participate In Practice (Hip),
Jarvis Brownlee: Limited Participation in Practice (Ankle)

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