Star quarterback Daniel Jones and the Indianapolis Colts (2-0) play the Tennessee Titans (0-2) on Sunday at 1 p.m. ET at Nissan Stadium.
The Titans have been sputtering offensively, ranking third-worst in the NFL with 15.5 points per game. They have been more productive on the other side of the ball, giving up 26.5 points per contest (23rd-ranked). The Colts have been finding success on both offense and defense, ranking best in total offense (445.5 yards per game) and fifth-best in total defense (267.5 yards allowed per game).
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Titans vs Colts: Live streaming info, TV channel & game timeGame day: Sunday, September 21, 2025Game time: 1 p.m. ETLocation: Nashville, TennesseeStadium: Nissan StadiumTV channel: CBSLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Paramount+! (Regional restrictions may apply)
Watch Indianapolis Colts vs. Tennessee Titans on Fubo! (Regional restrictions may apply)
Titans vs Colts betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Colts (-4.5)Moneyline: Colts (-227), Titans (+187)Total: 43.5 points
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