Division rivals Indianapolis (2-0) and Tennessee (0-2) will meet in a matchup of AFC South teams on Sunday, September 21, 2025 at Nissan Stadium. The Colts are listed as favorites in this one, with the spread sitting at 4.5 points. The over/under for the contest is 43.5 points.
The Colts’ most recent game was against the Denver Broncos, and they won by a score of 29-28.
Colts quarterback Daniel Jones was 23-for-34 for 316 yards, with one TD and no INTs, versus the Broncos.
The Titans‘ most recent game was against the Los Angeles Rams, and they lost by a score of 33-19.
Colts vs Titans betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 1:07 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Indianapolis (-4.5)Moneyline: Indianapolis (-227), Tennessee (+187)Total: 43.5 pointsColts betting insightsAway from home last season, Indianapolis was 4-5 against the spread, and 3-6 overall.The Colts have covered the spread in each of their two games with a set spread.Indianapolis was winless ATS (0-1) as 4.5-point favorites or more on the road.In nine road games last year, Indianapolis hit the over five times.Colts games have gone over the total once this season.Colts leadersJones: 588 PASS YDS / 294.0 YPG / 71.4% / 2 TD / 0 INT / 13 CAR / 28 RUSH YDS / 3 TDJonathan Taylor: 43 CAR / 236 YDS / 118.0 YPG / 0 TD / 5 REC / 77 YDS / 38.5 YPG / 1 TDDJ Giddens: 12 CAR / 41 YDS / 20.5 YPG / 0 TDTyler Warren: 11 REC / 155 YDS / 77.5 YPG / 0 TDMichael Pittman Jr.: 10 REC / 120 YDS / 60.0 YPG / 1 TDAlec Pierce: 5 REC / 104 YDS / 52.0 YPG / 0 TDColts vs Titans game infoDate: Sunday, September 21, 2025Time: 1 p.m. ETCity: Nashville, TennesseeVenue: Nissan StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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