The Indianapolis Colts are 3-0 for the first time since 2009 after disposing of the Tennessee Titans 41-20 in NFL Week 3 action. 

The Colts set the tone with Kenny Moore’s interception return for a touchdown in the game’s first minute. 

The Indianapolis offense continues its efficient play. Jonathan Taylor rushes for 102 yards and 3 touchdowns. Daniel Jones completes 18-of-25 passes for 228 yards and a touchdown to Michael Pittman Jr.

The Colts have not committed a turnover this season and have punted once. 

Tennessee rookie and No. 1 overall draft pick Cam Ward completes 23-of-38 passes for 219 yards, 1 touchdown and 1 interception. The Colts sack him 4 times. 

The Colts visit the Los Angeles Rams (2-1) in NFL Week 4 action.

Colts 41, Titans 20, 5:53 left 4Q: Jonathan Taylor bulls his way in from 2 yards. He has 102 yards and 3 touchdowns on 17 carries.

Colts 34, Titans 20, 8:40 left 4Q: Cam Ward hits Elic Ayomanor for an 8-yard touchdown. The drive takes 16 plays, 77 yards and 7:47. Ward is 22-of-35 passing for 216 yards.

Colts 34, Titans 13, 1:27 left 3Q: Jonathan Taylor breaks tackles on the way to a 46-yard touchdown run. He has 13 carries for 90 yards and 2 touchdowns. Daniel Jones converts a 4th-and-1 with a sneak as the Colts approach midfield.

Alec Pierce heads to the locker room after he landed awkwardly on a long incompletion.

That was an old-school HB Iso, right?

Get Warren on the linebacker and let JT cook?

— Joel A. Erickson (@JoelAErickson) September 21, 2025

Colts 27, Titans 13, 5:09 left 3Q: Tony Pollard scores from 1 yard for Tennessee’s first runing touchdown of the season. Julius Chestnut runs 27 yards to the Colts’ 4.

Colts 27, Titans 6, 11:08 left 3Q: Daniel Jones hits Michael Pittman Jr. in the middle, and Pittman completes the 20-yard touchdown.

Colts 20, Titans 6, halftime: Spencer Shrader connects from 36 yards as the first half ends.

The Colts quarterback is 10-of-16 passing for 141 yards, with 3 carries for 25 yards.

The Colts running back has 9 carries for 28 yards and a touchdown.

Pierce has 3 catches for 48 yards; Pittman has 3 catches for 27 yards.

The Titans rookie is 9-of-18 passing for 104 yards and 1 interception. He also has 2 carries for 9 yards.

The Titans running back has 9 carries for 31 yards.

Colts 17, Titans 6, :37 left 2Q: Joey Slye misses from 62 yards after Grover Stewart‘s deflection. Slye is 2-of-4 in the game. The Titans lose 5 yards on a delay of game penalty in field goal formation.

Colts 17, Titans 6, 3:15 left 2Q: Spencer Shrader misses a 51-yard field goal try to the right. He’s now 10-of-11 this season.

Looked to me like the snap on Shrader’s 51-yard attempt was a little off… Shrader misses.

— Joel A. Erickson (@JoelAErickson) September 21, 2025

Colts 17, Titans 6, 5:34 left 2Q: Joey Slye misses a 64-yard field goal try to the right. Cam Ward connects on his first 4 passes on that drive for 42 yards before the Colts stop the Titans. Ward is 9-of-18 passing for 104 yards.

Colts 17, Titans 6, 9:13 left 2Q: The Colts go 3-and-out. The Titans have it at their 9 after the Rigoberto Sanchez punt, his first this season.

Colts 17, Titans 6, 10:50 left 2Q: Joey Slye makes a 42-yard field goal. He is also 10-of-10 on field goals this season. Cam Ward is 5-of-12 passing for 62 yards, with 2 carries for 9 yards.

Colts 17, Titans 3, 1:07 left 1Q: Jonathan Taylor goes in from 1 yard for a touchdown. He has 5 carries for 8 yards. Indianapolis has 145 yards of offense, Tennessee 13.

Daniel Jones escapes an almost certain sack and gains 17 yards to reach Tennessee’s 25.

Colts 10, Titans 3, 5:16 left 1Q: Tyquan Lewis and Kwity Paye get to Cam Ward. The Colts have the ball at their 23 after a Titans punt.

Colts 10, Titans 3, 7:37 left 1Q: Spencer Shrader makes it 10-of-10 on field goals this season, this one from 24 yards. The Colts have 5 touchdowns in 13 red zone trips this season.

Daniel Jones hits Josh Downs for a 29-yard game into the red zone. Jones hits Alec Pierce for 16 yards into Titans territory.

Colts 7, Titans 3, 12:40 left 1Q: Joey Slye kicks his second 57-yarder of the season. Cam Ward is 1-of-5 passing for 22 yards.

Colts 7, Titans 0, 14:11 left 1Q: Kenny Moore intercepts the Cam Ward pass and easily takes it back 32 yards. Tennessee had won the coin toss and took the ball first.

That’s the earliest defensive touchdown in franchise history. Gary Brackett had a pick-6 with 13:08 left in the first quarter against Denver’s Jake Plummer in 2003.

The Indianapolis Colts and Tennessee Titans will play at 1 p.m. ET Sunday, Sept. 21, 2025.

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The Indianapolis Colts and Tennessee Titans will air on CBS at 1 p.m. ET Sunday, Sept. 21, 2025.

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The Indianapolis Colts and Tennessee Titans will stream on NFL+ at 1 p.m. ET Sunday, Sept. 21, 2025. Fans can download NFL+ in the Apple App Store or on Google Play.

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Radio: 93.5, 97.1 and 107.5 FM in Indianapolis, with Matt Taylor (play-by-play), Rick Venturi (analysis) and Larra Overton (sideline reporting)Stream: SiriusXM Channels 392 and 232 (Titans feed)

The injury report looks good for the Colts, but not so much for the Titans.

There’s a sense the Colts may stumble in their first road game this season. Here are the picks.

via BetMGMFavorite: Colts by 4 pointsOver/under: 43.5 total pointsMoneyline: Colts -210, Titans +170ESPN matchup predictor gives the Colts a 66.0% chance of winning.

(all times ET)

Thursday, Sept. 18: Buffalo Bills 31, Miami Dolphins 21, Amazon (summary, box score)Sunday, Sept. 21: Atlanta Falcons at Carolina Panthers, 1 p.m., Fox (summary, box score)Sunday, Sept. 21: Green Bay Packers at Cleveland Browns, 1 p.m., Fox (summary, box score)Sunday, Sept. 21: Houston Texans at Jacksonville Jaguars, 1 p.m., CBS (summary, box score)Sunday, Sept. 21: Cincinnati Bengals at Minnesota Vikings, 1 p.m., CBS (summary, box score)Sunday, Sept. 21: Pittsburgh Steelers at New England Patriots, 1 p.m., CBS (summary, box score)Sunday, Sept. 21: Los Angeles Rams at Philadelphia Eagles, 1 p.m., Fox (summary, box score)Sunday, Sept. 21: New York Jets at Tampa Bay Buccaneers, 1 p.m., Fox (summary, box score)Sunday, Sept. 21: Indianapolis Colts at Tennessee Titans, 1 p.m., CBS (summary, box score)Sunday, Sept. 21: Las Vegas Raiders at Washington Commanders, 1 p.m., Fox (summary, box score)Sunday, Sept. 21: Denver Broncos at Los Angeles Chargers, 4:05 p.m., CBS (summary, box score)Sunday, Sept. 21: New Orleans Saints at Seattle Seahawks, 4:05 p.m., CBS (summary, box score)Sunday, Sept. 21: Dallas Cowboys at Chicago Bears, 4:25 p.m., Fox (summary, box score)Sunday, Sept. 21: Arizona Cardinals at San Francisco 49ers, 4:25 p.m., Fox (summary, box score)Sunday, Sept. 21: Kansas City Chiefs at New York Giants, 8:20, NBC, Peacock, Universo (summary, box score)Monday, Sept. 22: Detroit Lions at Baltimore Ravens, 8:15 p.m., ESPN, ESPN2, ABC, ESPN Deportes (summary, box score)

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Week 1: Indianapolis Colts 33, Miami Dolphins 8, box score, statsWeek 2: Colts 29, Denver Broncos 28, box score, statsWeek 3: Sunday, Sept. 21, at Tennessee Titans, 1 p.m., CBSWeek 4: Sunday, Sept. 28, at Los Angeles Rams, 4:05 p.m., FoxWeek 5: Sunday, Oct. 5, vs. Las Vegas Raiders, 1 p.m., FoxWeek 6: Sunday, Oct. 12, vs. Arizona Cardinals, 1 p.m., FoxWeek 7: Sunday, Oct. 19, at Los Angeles Chargers, 4:05 p.m., CBSWeek 8: Sunday, Oct. 26, vs. Tennessee Titans, 4:25 p.m., CBSWeek 9: Sunday, Nov. 2, at Pittsburgh Steelers, 1 p.m., CBSWeek 10: Sunday, Nov. 9, vs. Atlanta Falcons in Berlin, Germany, 9:30 a.m., NFL NetworkWeek 11: ByeWeek 12: Sunday, Nov. 23, at Kansas City Chiefs, 1 p.m., CBSWeek 13: Sunday, Nov. 30, vs. Houston Texans, 1 p.m., CBSWeek 14: Sunday, Dec. 7, at Jacksonville Jaguars, 1 p.m., CBSWeek 15: Sunday, Dec. 14, at Seattle Seahawks, 4:25 p.m., CBSWeek 16: Monday, Dec. 22, vs. San Francisco 49ers, 8:15 p.m., ESPN‘s “Monday Night Football”Week 17: Sunday, Dec. 28, vs. Jacksonville Jaguars, 1 p.m., FoxWeek 18: Date TBD, at Houston Texans, time TBD, TBD

Joel A. Erickson covers the Colts all season. Get more coverage on IndyStarTV and with the Colts Insider newsletter.