The New Orleans Saints (0-3) visit the Buffalo Bills (3-0) at Highmark Stadium in Orchard Park for a Week 4 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, September 28, including live updated odds and injury report news.
Bills vs. Saints live odds, moneyline, over/under
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Bills vs. Saints picks against the spread
Jon Hoefling: New Orleans Saints (+16.5)
This is just too much. Two touchdowns is a lot. Yes, the Saints are bad, but they aren’t that bad and could certainly get some points in garbage time to make this game appear closer on the box score than it actually will be.
Blake Schuster: New Orleans Saints (+16.5)
New Orleans is bad, and the Bills are a legit Super Bowl threat but, come on, this is an absurd line. The Saints still have a run game capable of making this one more of a slog. This might be a trap game for Buffalo.
Tyler Dragon: Buffalo Bills (-16.5)
The Saints have no chance in this game. At some point New Orleans has to give Tyler Shough some snaps.
Richard Morin: New Orleans Saints (+16.5)
This is a big spread by NFL standards. I get nervous.
Christopher Bumbaca: New Orleans Saints (+16.5)
Too many points. Bills enter cruise control and win easily though.
Lorenzo Reyes: New Orleans Saints (+16.5)
I hate lines this big. I do think the Bills coast in this one, but I personally would stay away from anything that requires three scores.
Bills vs. Saints updated injury reportNFL Week 4 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 32025 RecordJon Hoefling10-626-20-2Tyler Dragon9-725-21-2Lorenzo Reyes9-725-21-2Chris Bumbaca7-924-22-2Jordan Mendoza9-724-22-2Blake Schuster8-824-22-2Super Bowl 60 updated odds