The Carolina Panthers (1-2) visit the New England Patriots (1-2) at Gillette Stadium in Foxborough for a Week 4 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, September 28, including live updated odds and injury report news.
Patriots vs. Panthers live odds, moneyline, over/under
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Patriots vs. Panthers picks against the spread
Jon Hoefling: Carolina Panthers (+5.5)
Carolina impressed in Week 3 and it probably rides this momentum into a solid showing against the New England Patriots. Drake Maye should have a solid day against this Carolina secondary though.
Blake Schuster: New England Patriots (-5.5)
I’m not sure what to make of either team, yet. But I do know New England isn’t as prone to mistakes as Atlanta, so it’s hard for me to get too excited about the Panthers walloping the Falcons in Week 3.
Tyler Dragon: Carolina Panthers (+5.5)
I’m still surprised the Panthers blewout the Falcons. I think the Patriots hang on at home, but it’s going to be close.
Richard Morin: Carolina Panthers (+5.5)
The Patriots may have added some talent in the offseason, but they’ve been unable to get out of their own way in 2025.
Christopher Bumbaca: Carolina Panthers (+5.5)
The Patriots could have hung 40 points last week if they hung onto the ball. That will be an easier task against the Panthers compared to the Steelers. But Bryce Young can still have a big day if the Pats are again without corner Christian Gonzalez.
Lorenzo Reyes: Carolina Panthers (+5.5)
Carolina is a confusing team. So are the Patriots. I would stay away here, but I think 5.5 is way too rich for a New England team that’s tied for 21st in scoring offense.
Patriots vs. Panthers updated injury reportNFL Week 4 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 32025 RecordJon Hoefling10-626-20-2Tyler Dragon9-725-21-2Lorenzo Reyes9-725-21-2Chris Bumbaca7-924-22-2Jordan Mendoza9-724-22-2Blake Schuster8-824-22-2Super Bowl 60 updated odds