The Buffalo Bills continue their 2025 NFL season with a matchup against the New Orleans Saints at home at Highmark Stadium in Week 4.
While game plans, coaching, and strategy will play a part, but sometimes a big emphasis will sit with some individual players. In terms of the Bills offense, who could those be?
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Here are three potential X-factors on the Bills (3-0) offense against the Saints (0-3) in Week 4:
RB James Cook
Sep 14, 2025; East Rutherford, New Jersey, USA; Buffalo Bills running back James Cook (4) rushes the ball against the New York Jets during the first half at MetLife Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images
No one wants to assume that the Bills offense will roll against the Saints, but there is a good possibility. If that is the case, Cook will be called upon early but also later on to kill the clock and game.
OL Spencer Brown
Jan 26, 2025; Kansas City, MO, USA; Buffalo Bills offensive tackle Spencer Brown (79) against the Kansas City Chiefs during the AFC Championship game at GEHA Field at Arrowhead Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images
Brown is battling a calf injury and there is a good chance he faces Saints pass rusher Carl Granderson. He leads New Orleans’ defense with 3.5 so far this season so the Bills will need their right tackle to stop him.
WR Keon Coleman
Sep 7, 2025; Orchard Park, New York, USA; Buffalo Bills wide receiver Keon Coleman (0) runs the ball during the fourth quarter against the Baltimore Ravens at Highmark Stadium. Mandatory Credit: Gregory Fisher-Imagn Images
Coleman could be matched up on the outside against Saints cornerback Kool-Aid McKinstry and safety Justin Reid over the top at safety. McKinstry is Pro Football Focus‘ 10th worst cornerback so far this season and Reid is not much better, PFF’s 12th worst safety in the NFL.
This article originally appeared on Bills Wire: 3 potential X-factors on the Bills offense vs. the Saints in Week 4