What we’re hearing on the Saints: Saints coach Kellen Moore expressed his confidence in starting QB Spencer Rattler following the loss to the Seahawks. Moore indicated the Saints wouldn’t be following the Giants’ lead and switching quarterbacks anytime soon, and said Rattler realizes how much confidence the team has in him. He thinks Rattler — who is 0-9 as a starter dating back to last season — is headed in the right direction. “It’s frustrating because Spencer hasn’t been able to get a win in this league, and he’s earned it and he deserves it. He’s done so much good,” Moore said. — Katherine Terrell

What we’re hearing on the Bills: Despite sitting on the largest point spread of the season, per ESPN BET, the emphasis from the Bills is that they are treating Sunday’s game like any other. QB Josh Allen said he expects the Saints “to have their ears pinned back. They want to win as badly as anybody in the league right now. And again, there’s no easy games in this league.” The Bills have a 13-game home winning streak in the regular season but could be without three starters (DT Ed Oliver, LB Matt Milano and RT Spencer Brown) due to injuries. — Alaina Getzenberg

Stat to know: The Bills have gone eight straight games without a turnover (including the playoffs), which is tied with the 2024 Chiefs for the longest streak with zero turnovers since 1933. — ESPN Research

Bold prediction: Saints LB Demario Davis will lead the NFL in combined tackles in Week 4. The Bills will get out to a lead so large that they will run the ball a ton. And Davis ranks second among linebackers in tackle rate versus run plays, earning a tackle or assist on 29% of opponent’s runs. — Walder

Fantasy nugget: The Bills are heavy home favorites against the Saints, which bodes well for RB James Cook. He has had 18-plus touches and 20-plus fantasy points in three straight games. Buffalo’s offensive line, the league leader in run block win rate (76.6%), should dominate a Saints front that has allowed the seventh-most fantasy points per game to running backs. In deeper formats, don’t overlook fellow RB Ty Johnson as a potential sleeper. See Week 4 rankings. — Moody

Betting nugget: Rattler is 1-8 ATS in his career as a starter.

Maldonado’s pick: Bills 35, Saints 14

Moody’s pick: Bills 34, Saints 16

Walder’s pick: Bills 33, Saints 7

FPI prediction: BUF, 80.5% (by an average of 13.1 points)