The New Orleans Saints (0-3) are monitoring seven players on their injury report as they ready for a Sunday, Sept. 28 matchup against the Buffalo Bills (3-0) at Highmark Stadium, which starts at 1 p.m. ET.
Watch Buffalo Bills vs. New Orleans Saints on Fubo! (Regional restrictions may apply)
Saints vs Bills TV channel & game infoGame day: Sunday, September 28, 2025Game time: 1 p.m. ETLocation: Orchard Park, New YorkStadium: Highmark StadiumTV channel: CBSLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Paramount+! (Regional restrictions may apply)
Watch Buffalo Bills vs. New Orleans Saints on Fubo! (Regional restrictions may apply)
Saints injury reportChase Young | DE (Out)Injury: CalfPractice Status: Did Not Participate In Practice2024 Defensive Performance: 5.5 Sacks | 8.0 Tackles for Loss | 31 Tackles | 0 Interceptions | 3 Passes DefendedDillon Radunz | OL (Out)Injury: ToePractice Status: Did Not Participate In Practice2025 Season Stats: 1 Games PlayedDevaughn Vele | WR (Questionable)Injury: HipPractice Status: Limited Participation in Practice2025 Season Stats: 2 Games PlayedTrevor Penning | OLInjury: ToePractice Status: Full Participation in Practice2025 Season Stats: 1 Games PlayedCameron Jordan | DEInjury: GroinPractice Status: Full Participation in Practice2025 Defensive Stats: 1.5 Sacks | 3.0 Tackles for Loss | 8 Tackles | 0 Interceptions | 1 Pass DefendedTrey Palmer | WRInjury: HamstringPractice Status: Full Participation in Practice2024 Season Stats: 14 Games PlayedTaliese Fuaga | OTInjury: KneePractice Status: Full Participation in Practice2025 Season Stats: 1 Games PlayedSaints insightsIn terms of total offense, the Saints rank 19th in the NFL (302 total yards per game) and 15th on the other side of the ball (313.3 total yards allowed per game).With 199.7 passing yards per game on offense, the Saints rank 18th in the NFL. On defense, they rank 18th, allowing 210 passing yards per contest.New Orleans racks up 302 yards per game, just 14.7 more than the 287.3 Buffalo gives up.Saints vs Bills odds
NFL odds courtesy of BetMGM. Odds updated Saturday at 1:24 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-15.5)Moneyline: Bills (-1613), Saints (+893)Total: 48.5 points
Watch Buffalo Bills vs. New Orleans Saints on Fubo! (Regional restrictions may apply)